NDLI: The protective effect of glycitin on UV-induced skin photoaging in human primary dermal fibroblast

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The protective effect of glycitin on UV-induced skin photoaging in human primary dermal fibroblast

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Journal of the Korean Society for Applied Biological Chemistry : Volume 57, Issue 3, June 2014

Journal of the Korean Society for Applied Biological Chemistry : Volume 57, Issue 2, April 2014

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The protective effect of glycitin on UV-induced skin photoaging in human primary dermal fibroblast

Content Provider	Springer Nature Link
Author	Park, Sanggyu Huh, Jung Sik Seo, Ga Young Cho, Moonjae
Copyright Year	2014
Abstract	Exposure of strong and repeated UV on the skin leads to skin aging, characterized with wrinkling, sagging, dyspigmentation, and laxity. Numerous studies revealed that Matrix metalloproteinases are related to skin aging and functions as degrading enzyme of various types of collagen. Here, we attempted to evaluate the effectiveness of glycitin (4′-hydroxy-6-methoxyisoflavone- 7-d-glucoside) on skin aging and mechanisms of action in UV-irradiated human dermal fibroblasts. Especially we focused on the expression of Matrix metalloproteinase-1 (MMP-1), which degrades procollagen type-I in dermis, by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, Western blot, and reverse transcription polymerase chain reaction in cell lysates or media. Our results showed that glycitin increased the viability of human dermal fibroblast and alleviated MMP-1 expression caused by UV irradiation. In addition, synthesis of type-I collagen was increased and UV-induced phosphorylation of ERK/JNK/p38 was decreased in dose-dependent manners. Taken together, we demonstrated that treatment with glycitein have a protective effect on skin aging by inhibiting of MMP-1 and increasing of collagen through ERK/JNK/P38 down-regulation, which may be mediated by the inhibition of ERK, JNK, and p38 mitogen-activated protein kinases. We suggest that glycitin is a potential agent for the treatment of skin ageing.
Starting Page	463
Ending Page	468
Page Count	6
File Format	PDF
ISSN	17382203
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	57
Issue Number	4
e-ISSN	2234344X
Language	English
Publisher	The Korean Society for Applied Biological Chemistry
Publisher Date	2014-07-21
Publisher Place	Seoul
Access Restriction	Subscribed
Subject Keyword	human dermal fibroblast UV 4′-hydroxy-6-methoxyisoflavone-7-D-glucoside collagen type-I Applied Microbiology Biological Techniques matrix metalloproteinase-1 Bioorganic Chemistry skin ageing
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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