NDLI: Article Inhibitory Effects of Elsholtzia ciliata Extract on Fat Accumulation in High-fat Diet-induced Obese Mice

Content Provider	Springer Nature Link
Author	Sung, Yoon Young Kim, Seung Ju Kim, Ho Kyoung Yoon, Taesook Yang, Won kyung
Copyright Year	2003
Abstract	Anti-obese effects of an ethanol extract of Elsholtzia ciliata (Elsholtzia ciliata extract, ECE) in high-fat diet-induced obese mice were investigated. The body weight gain, weights of adipose tissues, and adipocyte size were reduced in ECE-treated obese mice compared to those in high-fat diet-induced obese mice. ECE treatment also resulted in significant decreases in serum total cholesterol, triglyceride, and leptin concentrations, relative to concentrations in untreated obese mice. Furthermore, ECE significantly suppressed the elevated mRNA expression levels of peroxisome proliferator-activated receptor γ, fatty acid synthase, and adipocyte fatty acid-binding protein in the subcutaneous adipose tissue of obese mice. In addition, ECE treatment inhibited 3T3-L1 preadipocyte differentiation and fat accumulation. These results suggest that ECE ameliorated high-fat diet-induced obesity by downregulating expression of some lipogenesis-related genes in the fat tissue of mice.
Starting Page	388
Ending Page	394
Page Count	7
File Format	PDF
ISSN	17382203
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	54
Issue Number	3
e-ISSN	2234344X
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-01-01
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	adipocyte high-fat diet Applied Microbiology Biological Techniques lipogenesis Elsholtzia ciliata leptin Bioorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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Article Inhibitory Effects of Elsholtzia ciliata Extract on Fat Accumulation in High-fat Diet-induced Obese Mice

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Article Inhibitory Effects of Elsholtzia ciliata Extract on Fat Accumulation in High-fat Diet-induced Obese Mice