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Complexes of Co (II) and Cu (II) with nonsteroidal anticancer drug Letrozole and their interaction with DNA and BSA by spectroscopic methods and cytotoxic activity

Content Provider	Springer Nature Link
Author	Waqif Husain, S. Alireza Esmaeili, S. Tavakolyanpour, F. Abroomand Azar, P. Rastegar, M. H. Momtazi Borojeni, A. A. Saber Tehrani, M.
Copyright Year	2016
Abstract	DNA and BSA binding properties of mononuclear Co (II) and Cu (II) complexes containing letrozole [M(Le)$_{4}$Cl$_{2}$]·(H2O)](Le=[4,4-(1H-1,2,4-triazol-1-ylmethylene)bisbenzonitrile] have been investigated under physiological conditions. The interaction ability of the two complexes with native calf thymus DNA(CT-DNA) has been monitored as a function of the metal complex-DNA molar ratio by UV–Vis absorption spectrophotometry, fluorescence spectroscopy, circular dichroism(CD) and thermal denaturation studies. The intrinsic binding constants, K$_{b}$, of complexes 1 and 2 with CT-DNA, obtained from UV–Vis absorption studies, were 3.15 ± 0.02 × 10$^{4}$ and 4.37 ± 0.02 × 10$^{4}$ M$^{−1}$, respectively. The addition of the complexes to CT-DNA (1:2) leads to an increase in the melting temperature of DNA up to around 4 °C, which has revealed that complexes could interact with DNA through intercalation mode. Fluorimetric studies have been performed using methylene blue (MB) as a fluorescence probe and competitive studies have shown the ability of the complexes to displace the DNA-bound MB, suggesting competition with MB. To explore the potential biological value of the complexes, the binding interaction between Co (II) and Cu (II) complexes and bovine serum albumin (BSA) has also been studied by fluorescence spectroscopy. The results indicate that the reaction between the complexes and BSA is a static quenching procedure. The site marker displacement experiment has suggested the location of the complexes binding to BSA at Sudlow’s site I in subdomain IIA. Finally, MTT assay studies have shown that the bioactive complexes exert significantly high selective dose-dependent cytotoxicity against a panel of cancer cell lines including MCF-7, JURKAT, SKOV3 and U87.
Starting Page	2121
Ending Page	2133
Page Count	13
File Format	PDF
ISSN	1735207X
Journal	Journal of the Iranian Chemical Society
Volume Number	13
Issue Number	11
e-ISSN	17352428
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-07-08
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	CT-DNA Spectrometry Analytical Chemistry Physical Chemistry Site markers Biochemistry Inorganic Chemistry BSA binding Letrozole Organic Chemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry

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