NDLI: Nanoparticles-induced inflammatory cytokines in human plasma concentration manner: an ignored factor at the nanobio-interface

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Nanoparticles-induced inflammatory cytokines in human plasma concentration manner: an ignored factor at the nanobio-interface

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Nanoparticles-induced inflammatory cytokines in human plasma concentration manner: an ignored factor at the nanobio-interface

Content Provider	Springer Nature Link
Author	Mahmoudi, Morteza Tirtaatmadja, Nicolin Ahmad, Hacan Ali Serpooshan, Vahid Mortimer, Gysell Minchin, Rodney F. Ng, Eng Poh Mintova, Svetlana
Copyright Year	2014
Abstract	Properties of nanoparticles (NPs) are responsible for their interaction with various biomolecules such as proteins in biological environments. Amount and composition of the proteins associated with NPs, i.e. protein corona, are strongly dependent on physicochemical characteristics of the particles, as well as incubation parameters including temperature and protein concentration. More importantly, the protein corona can define the biological fate of the NPs. Here, we demonstrate that variations in the concentration of plasma protein led to significant changes in the composition of the hard corona adsorbed on the surface of different NPs including hydrophilic amorphous silica (SiO$_{2}$), hydrophilic crystalline zeolite (EMT), and hydrophobic sulfonated-modified polystyrene. Alteration in the corona composition of the NPs is a result of the plasma concentration, i.e. it affects the release of inflammatory cytokines in a plasma concentration-dependent manner. The amorphous silica nanoparticles with hydrophilic surfaces induced the release of the inflammatory cytokines interleukin-8 (IL-8) and tumor necrosis factor (TNFα) in 10 % plasma concentration, but not at higher concentrations. A reverse trend was observed for the hydrophobic, sulfonated-modified polystyrene NPs. Remarkably the hydrophilic highly porous EMT NPs exhibited no cellular toxicity regardless to the plasma concentration. The results obtained in this study can be used to define optimal pathways for nanoparticles administration in vivo. These findings can assist researchers to better understand how NPs with different surface properties may interact with various proteins in vivo, and elucidate safety considerations for their biomedical applications.
Starting Page	317
Ending Page	323
Page Count	7
File Format	PDF
ISSN	1735207X
Journal	Journal of the Iranian Chemical Society
Volume Number	12
Issue Number	2
e-ISSN	17352428
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-07-24
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Nanoparticles Administrative routes Analytical Chemistry Toxicity Physical Chemistry Inflammation Biochemistry Inorganic Chemistry Protein corona Organic Chemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry

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