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| Content Provider | Springer Nature Link |
|---|---|
| Author | Nerkar, Pankaj Ige, Pradum Pundlikrao Belgamwar, Veena Rajput, Pravin Mahajan, Hitendra Swami, Bramhanand Surana, Sanjay Gattani, Surendra Pardeshi, Chandrakantsingh Kawade, Rajendra |
| Copyright Year | 2013 |
| Abstract | Polymeric mucoadhesive pellets of nifedipine were designed using computer software and they were prepared by extrusion-spheronization using HPMC K15M and κ-carrageenan with microcrystalline cellulose. A randomized rotatable two factor central composite design was applied for assessment of influence of two independent variables such as concentration of κ-carrageenan and HPMC K15M on dependent variables. Pellets were characterized by FTIR, DSC, SEM, flow properties, particle size, abrasion resistance, sphericity, drug content, percent production yield, in vitro drug release, ex vivo mucoadhesion, stability studies and similarity factor. The optimized formulation was selected based on criteria of sphericity nearest to 1.0 with maximum cumulative drug release percentage. Formulation NF6 exhibited sufficient porous spheres, free flowing and smooth surface mucoadhesion of 91.34 % and drug content 98.22 ± 0.37 %. Kinetic modeling revealed that the formulation followed the Higuchi model and showed the Quassi-Fickian drug release mechanism. The similarity factor, F2 value, was found to be 74 ± 6 and there was no significant change in drug content and ex vivo mucoadhesion after 90 days at 40 ± 2 °C, and 75 ± 5 % RH clearly indicated the optimized batch NF6 was stable. Thus, it can be concluded that use of κ-carrageenan, microcrystalline cellulose and HPMC K15M at the 20:35:10 w/w ratio could provide an effective carrier for enhancement of sphericity and sustained release of matrix pellets. |
| Starting Page | 911 |
| Ending Page | 921 |
| Page Count | 11 |
| File Format | |
| ISSN | 10261265 |
| Journal | Iranian Polymer Journal |
| Volume Number | 22 |
| Issue Number | 12 |
| e-ISSN | 17355265 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2013-09-30 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Polymer Sciences Matrix pellets Central composite design Extrusion-spheronization κ-Carrageenan Ceramics, Glass, Composites, Natural Methods Nifedipine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Materials Chemistry Chemical Engineering Polymers and Plastics |
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