NDLI: Inhibitory activity of the protein carbonylation and hepatoprotective effect of the ethanol-soluble extract of Caesalpinia coriaria Jacq

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Inhibitory activity of the protein carbonylation and hepatoprotective effect of the ethanol-soluble extract of Caesalpinia coriaria Jacq

Content Provider	Springer Nature Link
Author	Pájaro González, Y. Méndez Cuadro, D. Fernández Daza, E. Franco Ospina, L. A. Redondo Bermúdez, C. Díaz Castillo, F.
Copyright Year	2016
Abstract	Free radical oxygen species cause protein carbonylation, an irreversible oxidative damage associated with diseases such as liver injury, diabetes mellitus, arthritis, cancer and Alzheimer. To determine the inhibitory activity of the protein carbonylation and the hepatoprotective effect of ethanol extract of the fruits of Caesalpinia coriaria Jacq (Fabaceae). Scavenging activity of 2,2-diphenyl-1- picrylhydrazyl radical (DPPH$^{•}$) and the radical cation 2,2’-azino-bis(3-ethylbenzothiazoline-sulfonic acid) (ABTS$^{•+}$) of the extract of C. coriaria at 500 mg / L, was evaluated in a preliminary test. Inhibitory activity of the protein carbonylation isolated from mouse liver using Western methodology with dinitrophenylhydrazine (DNPH) probes was evaluated. The hepatoprotective activity of the extract was evaluated in vivo in Wistar rats using carbon tetrachloride (CCl$_{4}$) as toxic orally. The degree of hepatoprotection was determined by measuring the serum liver enzymes, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and by histopathological analysis of rat liver. The rate of capture of the radicals DPPH$^{•}$ and ABTS$^{•+}$ by the extract of C. coriaria was higher than 90 % in both cases. The extract also showed a better inhibitory effect on the carbonylation of the proteins than butyl hydroxytoluene (BHT) used as positive control. The extract of C. coriaria produced a significant reduction of AST concentration (from 1667,67 ± 394,27 to 718,00 ± 24,85 U/L ) and ALT (from 967,67 ± 118,30 to 625.67 ± 60,98 U/L), indicating liver cell damage attenuation. The extract of C. coriaria produced an important antioxidant activity and moderate hepatoprotective effect against CCl$_{4}$-induced toxicity.
Starting Page	225
Ending Page	232
Page Count	8
File Format	PDF
ISSN	15982386
Journal	Oriental Pharmacy and Experimental Medicine
Volume Number	16
Issue Number	3
e-ISSN	22111069
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-05-31
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Hepatoprotective activity Antioxidants Western blot Proteins carbonylation Liver enzymes Aspartate aminotransferase Alanine aminotransferase Biomedicine general Pharmacy
Content Type	Text
Resource Type	Article
Subject	Complementary and Alternative Medicine

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