NDLI: Evaluation of hepatoprotective activity of ethanol extract of Coccinia grandis (L.) Voigt. leaves on experimental rats by acute and chronic models

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Oriental Pharmacy and Experimental Medicine : Volume 12, Issue 1, March 2012

Oriental Pharmacy and Experimental Medicine : Volume 11

Evaluation of hepatoprotective activity of ethanol extract of Coccinia grandis (L.) Voigt. leaves on experimental rats by acute and chronic models

Content Provider	Springer Nature Link
Author	Kundu, Mintu Mazumder, Rupa Kushwaha, M. D.
Copyright Year	2012
Abstract	Coccinia grandis Linn. (Cucurbitaceae) is a climbing perennial branched herb, distributed throughout India. Other plants under the same family have been reported for their hepatoprotective activity. The aim of this work was to study the hepatoprotective effect of crude ethanolic extract from the leaves of C. grandis against liver damage induced by Paracetamol and CCl$_{4}$ in rats. Administration of Paracetamol (750 mg/kg/day) and CCl$_{4}$ (3 ml/kg/day) showed a marked increase in SGOT, SGPT, ALP, bilirubin (total, direct), total proteins, globulin, cholesterol and decrease in albumin in comparison with the normal control group. The effect of ethanol extract of C. grandis at 150 mg/kg and 300 mg/kg doses reduced the serum activities caused by Paracetamol and CCl$_{4}$, which were observed to be statistically significant when compared with that of the control group. The activity exhibited/inhibited by the plant extract was found to be comparable to that of the standard hepatoprotective drug, Silymarin. Silymarin provided a better inhibition or exhibition of the biochemical parameters induced by paracetamol and carbon tetrachloride in rats. The activity may be due to the presence of either alkaloids or triterpenoids or reducing sugars or their combinations, as obtained from the preliminary phytochemical screening of the leaves of the plant. The extract showed no signs of acute toxicity up to a dose level of 3.2 g kg$^{−1}$ in rats by oral route. Thus, it could be concluded that ethanolic extract of C. grandis leaves possessed significant hepatoprotective activity.
Starting Page	93
Ending Page	97
Page Count	5
File Format	PDF
ISSN	15982386
Journal	Oriental Pharmacy and Experimental Medicine
Volume Number	12
Issue Number	2
e-ISSN	22111069
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-02-14
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Coccinia grandis Hepatoprotective Paracetamol Carbon tetrachloride Biochemical parameters Ethanol extract Pharmacy Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Complementary and Alternative Medicine

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HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF COCCINIA GRANDIS ROOT EXTRACT AGAINST PARACETAMOL INDUCED HEPATIC OXIDATIVE STRESS IN WISTAR ALBINO RATS

Hepatoprotective Activity of Coccinia grandis Leaves Against Carbon Tetrachloride Induced Hepatic Injury in Rats

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Evaluation of hepatoprotective activity of ethanol extract of Coccinia grandis (L.) Voigt. leaves on experimental rats by acute and chronic models

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