NDLI: Antioxidant and antiparkinsonian activity of Passiflora incarnata leaves

Content Provider	Springer Nature Link
Author	Ingale, Suvarna P. Kasture, Sanjay B.
Copyright Year	2014
Abstract	Herbal remedies for human brain disorders are much preferred over synthetic drugs because of various side effects of synthetic drugs ranging from sleep disorders to withdrawal syndromes. Passiflora incarnata Linn (Passifloraceae) has been widely used in traditional medicine in West India, Mexico, the Netherlands, and South America. It has been used as an anxiolytic and sedative-hypnotic since ancient times. The main constituents of leaves of P. incarnata are flavonoid and indole alkaloids based on β -carboline ring system viz., harman, harmine, harmalol and harmaline. Harmine and harmaline alkaloids are reported to be effective antiparkinsonian compounds. The objective of present investigation was to evaluate antiparkinsonian activity and antioxidant activity of butanol extract of P. incarnata leaves (BEPI). Antiparkinsonian activity of BEPI was studied using haloperidol induced catalepsy and tacrine induced jaw movements. The antioxidant activity of BEPI was studied using DPPH scavenging assay and H$_{2}$O$_{2}$ scavenging assay. The results of present study has shown that butanol extract of P. incarnata leaves (BEPI) (150 mg kg$^{−1}$ and 300 mg kg$^{−1}$, i.p.) significantly (p ≤ 0.001) reduced the duration of haloperidol induced catalepsy as well as tacrine induced jaw movements. BEPI has also shown significant antioxidant effect. The result obtained in current study indicates that BEPI posses antiparkinsonian as well as antioxidant activity which may be useful in symptomatic relief of PD and to prevent progression of PD.
Starting Page	231
Ending Page	236
Page Count	6
File Format	PDF
ISSN	15982386
Journal	Oriental Pharmacy and Experimental Medicine
Volume Number	14
Issue Number	3
e-ISSN	22111069
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-03-05
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Antioxidant activity Antiparkinsonian activity DPPH scavenging activity Haloperidol Tacrine Biomedicine general Pharmacy
Content Type	Text
Resource Type	Article
Subject	Complementary and Alternative Medicine

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