NDLI: Evaluation of anti-inflammatory and antioxidant potential of the kernel root of Xylocarpus mekongensis (Lamk.) M. Roem

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Oriental Pharmacy and Experimental Medicine : Volume 12, Issue 2, June 2012

Oriental Pharmacy and Experimental Medicine : Volume 12, Issue 1, March 2012

Oriental Pharmacy and Experimental Medicine : Volume 11

Evaluation of anti-inflammatory and antioxidant potential of the kernel root of Xylocarpus mekongensis (Lamk.) M. Roem

Content Provider	Springer Nature Link
Author	Jahan, Ismet Ara Hossain, Md. Hemayet Nimmi, Ishrat Islam, Siblara Kawsar, Md. Hassan Islam, Md. Amirul
Copyright Year	2012
Abstract	Anti-inflammatory and antioxidant activities of the crude ethanolic extract of the kernel root of Xylocarpus mekongenesis (Lamk.) M. Roem. (Meliaceae) was evaluated in different methods. The extract showed significant anti-inflammatory activity in carrageenan-induced oedema test in rats showing 69.42 % reduction in the paw volume (P < 0.01) comparable to that produced by the standard drug indomethacin (70.25 %) at 24 h when the extract was fed at the dose of 400 mg/kg body weight. The percentage inhibition of the oedema paw volume was statistically significant (p < 0.05) when compared with the indomethacin treated animals at 0.5, 1, 2, 4 and 6 h. The extract exhibited IC$_{50}$ value 4.78 μg/ml in DPPH free radical scavenging activity test that was found to be very significant and comparable to that of the standard antioxidants ascorbic acid and BHA (1.9372 and 4.81 μg/ml) respectively. In nitric oxide radical scavenging test, the IC$_{50}$ value was also found fairly significant 57.37 μg/ml when compared to standard ascorbic acid (36.81 μg/ml). In reducing power test, the maximum absorbance of the same extract was observed as 1.923 at 100 μg/ml and that of ascorbic acid and BHA were 2.8111 and 1.0314 respectively. The extract showed highest antioxidant capacity at 100 μg/ml concentration expressed as equivalents of ascorbic acid (1.44). The total phenolic content of the extract was also found quite high (342.15 ± 0.92 mg/g of gallic acid equivalent). Therefore, the results of this study suggest the probable anti-inflammatory and antioxidant activities of the ethanolic extract of X. mekongenesis kernel root and justify its use in traditional medicines.
Starting Page	181
Ending Page	188
Page Count	8
File Format	PDF
ISSN	15982386
Journal	Oriental Pharmacy and Experimental Medicine
Volume Number	12
Issue Number	3
e-ISSN	22111069
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-04-25
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Xylocarpus mekongensis Anti-inflammatory DPPH free-radical scavenging Nitric oxide scavenging Reducing power Total antioxidant capacity Total phenolic Pharmacy Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Complementary and Alternative Medicine

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