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Derivation, characterization and differentiation of a new human embryonic stem cell line from a Chinese hatched blastocyst assisted by a non-contact laser system

Anticancer drug sensitivity testing using an oxygen electrode apparatus

Establishment of induced pluripotent stem cells from human neonatal tissues

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Anticancer drug sensitivity testing using an oxygen electrode apparatus

Content Provider	Springer Nature Link
Author	Suzuki, Minako Ishikawa, Hiroshi Tanaka, Akira Mataga, Izumi
Copyright Year	2010
Abstract	Conventional anticancer drug sensitivity testing methods, such as succinate dehydrogenase inhibition (SDI), histoculture drug-response assay (HDRA) and collagen gel droplet embedded culture drug sensitivity testing (CD-DST), all require primary culturing and are extremely complex tests that require considerable time for analysis. A major drawback of these methods is that if culturing is not performed properly, ambiguous results are produced. Therefore, we developed an oxygen electrode apparatus that uses cellular metabolism as an indicator of anticancer drug sensitivity and investigated its usefulness in 29 breast cancer patients with the following histopathological classifications: papillotubular carcinoma (n = 15); solid tubular carcinoma (n = 6); and scirrhous carcinoma (n = 8). Comparison of anticancer drug sensitivity testing results obtained using the conventional HDRA method and those obtained using the oxygen electrode apparatus showed significant reproducibility between the two methods. In addition, similar anticancer drug sensitivity testing results using the oxygen electrode apparatus were obtained for in vivo testing of nude mice transplanted with established cancer cell lines. These findings suggest that the oxygen electrode apparatus is a useful procedure in anticancer drug sensitivity testing that provides better reproducibility and that is faster, more convenient, and less expensive than other testing methods.
Starting Page	103
Ending Page	112
Page Count	10
File Format	PDF
ISSN	09147470
Journal	Human Cell
Volume Number	23
Issue Number	3
e-ISSN	17490774
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-01-01
Publisher Place	Tokyo
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	anticancer drug sensitivity testing breast cancer oxygen electrode Cell Biology Embryology Oncology Stem Cells Reproductive Medicine Cell Culture
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Cancer Research

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