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| Content Provider | Springer Nature Link |
|---|---|
| Author | Fujioka, Tsuyoshi Shimizu, Natsumi Yoshino, Kaori Miyoshi, Hiroyuki Nakamura, Yukio |
| Copyright Year | 2010 |
| Abstract | Following the success in establishing human induced pluripotent stem (iPS) cells, research into various applications of the cells derived from human iPS cells has begun in earnest. The use of iPS cell-derived cells in clinical therapies is one of the most exciting of the possible applications. However, the risk of tumorigenicity is the biggest potential obstacle to use iPS cell derivatives in the clinic. It should be noted that the human cells used to generate iPS cell lines may have acquired genetic mutations and these might influence the tumorigenicity of the cells. In particular, the cells of older people have a higher risk of genetic mutations than those of younger people. Here, we show that iPS cells could be derived from short-term cultures of neonatal tissues. The established human iPS cells expressed various markers of undifferentiated cells and formed teratoma in immunodeficient mice. The human iPS cells derived from neonatal tissues may represent a clinical material possessing less tumorigenicity. |
| Starting Page | 113 |
| Ending Page | 118 |
| Page Count | 6 |
| File Format | |
| ISSN | 09147470 |
| Journal | Human Cell |
| Volume Number | 23 |
| Issue Number | 3 |
| e-ISSN | 17490774 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2010-01-01 |
| Publisher Place | Tokyo |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | clinical application neonatal tissue induced pluripotent stem cells Cell Biology Embryology Oncology Stem Cells Reproductive Medicine Cell Culture |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Cancer Research |
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