NDLI: Carnosic acid disrupts toll-like receptor 2 signaling pathway in Pam$_{3}$CSK$

Please wait, while we are loading the content...

Toxicology and Environmental Health Sciences : Volume 9

Toxicology and Environmental Health Sciences : Volume 8

Toxicology and Environmental Health Sciences : Volume 7

Toxicology and Environmental Health Sciences : Volume 7, Issue 5, December 2015

Toxicology and Environmental Health Sciences : Volume 7, Issue 4, October 2015

Toxicology and Environmental Health Sciences : Volume 7, Issue 3, September 2015

Chronic inhalation/carcinogenicity studies and their applications to prevent the occupational cancers: A review of recent reports

Sample preparation for optimal proteomic profiling of rabbit muscle and tendon using radio-immunoprecipitation assay (RIPA) and urea lysis buffers

Proteomic profiling of pig heart and lung samples using 2-dimensional gel electrophoresis

Soil trace elements contamination in the vicinity of Khatoon Abad copper smelter, Kerman province, Iran

Effects of hydrozoan colonization on biochemical compositions of the brown seaweed Saccharina japonica

Analysis of the body pressure-related sensory changes in the static supine position for healthy science research: a randomized controlled pilot trial

Cadmium modulates the mRNA expression and activity of glutathione S-transferase in the monogonont Rotifer Brachionus koreanus

Carnosic acid disrupts toll-like receptor 2 signaling pathway in Pam$_{3}$CSK$_{4}$-stimulated macrophages

Chlorin e6-mediated photodynamic inactivation with halogen light against microbes and fungus

Erratum to: The relationship between formaldehyde exposure levels and environmental diseases within residential environments

Toxicology and Environmental Health Sciences : Volume 7, Issue 2, June 2015

Toxicology and Environmental Health Sciences : Volume 7, Issue 1, March 2015

Toxicology and Environmental Health Sciences : Volume 6

Toxicology and Environmental Health Sciences : Volume 5

Toxicology and Environmental Health Sciences : Volume 4

Toxicology and Environmental Health Sciences : Volume 3

Toxicology and Environmental Health Sciences : Volume 2

Toxicology and Environmental Health Sciences : Volume 1

Carnosic acid disrupts toll-like receptor 2 signaling pathway in Pam$_{3}$CSK$_{4}$-stimulated macrophages

Content Provider	Springer Nature Link
Author	Park, Mi Young
Copyright Year	2015
Abstract	Carnosic acid (CA) is a major bioactive component of rosemary (Rosmarinus officinalis) leaves and is known to exhibit anti-inflammatory activities. However, its molecular action in the inflammatory process has not been fully elucidated. In the present study, the anti-inflammatory effect of CA on Toll-like receptor 2 (TLR2) pathways in the Pam$_{3}$CSK$_{4}$-stimulated macrophage was investigated. Bone marrowderived macrophages (BMDM) were treated with CA (0-30 μM) for 1 h followed by Pam$_{3}$CSK$_{4}$ for 1 h, and then the mRNA expression levels and the production levels of cytokines were measured. Next, TLR2-related molecules were measured in Pam$_{3}$CSK$_{4}$-stimulated RAW264.7 macrophages. The results showed that CA significantly suppressed the secretion and mRNA expression of proinflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) in Pam$_{3}$CSK$_{4}$-stimulated BMDM. TLR2 mRNA expression, nuclear factorkappa B (NF-κB) activation, and mitogen-activated protein kinase (MAPK) phosphorylation were markedly diminished with CA (10 μM and 30 μM) in Pam$_{3}$CSK$_{4}$-stimulated macrophages. In conclusion, the anti-inflammatory activity of CA is partly due to modulation of the TLR2 and MAPK/NF-κB signaling pathway in macrophages.
Starting Page	224
Ending Page	230
Page Count	7
File Format	PDF
ISSN	20059752
Journal	Toxicology and Environmental Health Sciences
Volume Number	7
Issue Number	3
e-ISSN	22337784
Language	English
Publisher	Korean Society of Environmental Risk Assessment and Health Science
Publisher Date	2015-11-03
Publisher Place	Seoul
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Carnosic acid Toll-like receptor 2 (TLR2) Macrophage Mitogen-activated protein kinase (MAPK) Nuclear factor-kappa B (NF-κB) Pharmacology/Toxicology Environmental Health
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4 (TLR4)-Related Nuclear Factor kappa b (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways.

An immune-stimulating proteoglycan from the medicinal mushroom Huaier up-regulates NF-κB and MAPK signaling via Toll-like receptor 4

A Novel Chinese Medicine, Xinfeng Capsule, Modulates Proinflammatory Cytokines via Regulating the Toll-Like Receptor 4 (TLR4)/Mitogen-Activated Protein Kinase (MAPK)/Nuclear Kappa B (NF-κB) Signaling Pathway in an Adjuvant Arthritis Rat Model.

An immune-stimulating proteoglycan from the medicinal mushroom Huaier up-regulates NF-κB and MAPK signaling via Toll-like receptor 4

Toll-like receptor 2-mediated NF-kappa B pathway activation in ocular surface epithelial cells

Anti-inflammatory effects of cordycepin in lipopolysaccharide-stimulated RAW 264.7 macrophages through Toll-like receptor 4-mediated suppression of mitogen-activated protein kinases and NF-κB signaling pathways

Herbal formula SC-E1 suppresses lipopolysaccharide-stimulated inflammatory responses through activation of Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages

TLR2 Ligand Pam3CSK4 Regulates MMP-2/9 Expression by MAPK/NF-κB Signaling Pathways in Primary Brain Microvascular Endothelial Cells.

Pmorf0222, a Virulence Factor in Pasteurella multocida, Activates Nuclear Factor Kappa B and Mitogen-Activated Protein Kinase via Toll-Like Receptor 1/2.

Carnosic acid disrupts toll-like receptor 2 signaling pathway in Pam$_{3}$CSK$_{4}$-stimulated macrophages

Similar Documents

Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4 (TLR4)-Related Nuclear Factor kappa b (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways.

An immune-stimulating proteoglycan from the medicinal mushroom Huaier up-regulates NF-κB and MAPK signaling via Toll-like receptor 4

A Novel Chinese Medicine, Xinfeng Capsule, Modulates Proinflammatory Cytokines via Regulating the Toll-Like Receptor 4 (TLR4)/Mitogen-Activated Protein Kinase (MAPK)/Nuclear Kappa B (NF-κB) Signaling Pathway in an Adjuvant Arthritis Rat Model.

An immune-stimulating proteoglycan from the medicinal mushroom Huaier up-regulates NF-κB and MAPK signaling via Toll-like receptor 4

Toll-like receptor 2-mediated NF-kappa B pathway activation in ocular surface epithelial cells

Anti-inflammatory effects of cordycepin in lipopolysaccharide-stimulated RAW 264.7 macrophages through Toll-like receptor 4-mediated suppression of mitogen-activated protein kinases and NF-κB signaling pathways

Herbal formula SC-E1 suppresses lipopolysaccharide-stimulated inflammatory responses through activation of Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages

TLR2 Ligand Pam3CSK4 Regulates MMP-2/9 Expression by MAPK/NF-κB Signaling Pathways in Primary Brain Microvascular Endothelial Cells.

Pmorf0222, a Virulence Factor in Pasteurella multocida, Activates Nuclear Factor Kappa B and Mitogen-Activated Protein Kinase via Toll-Like Receptor 1/2.

Carnosic acid disrupts toll-like receptor 2 signaling pathway in Pam$_{3}$CSK$_{4}$-stimulated macrophages