NDLI: Genetic gains and losses in oral squamous cell carcinoma: impact on clinical management

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Genetic gains and losses in oral squamous cell carcinoma: impact on clinical management

Content Provider	Springer Nature Link
Author	Ribeiro, Ilda Patrícia Marques, Francisco Caramelo, Francisco Pereira, João Patrício, Miguel Prazeres, Hugo Ferrão, José Julião, Maria José Castelo Branco, Miguel Melo, Joana Barbosa Baptista, Isabel Poiares Carreira, Isabel Marques
Copyright Year	2013
Abstract	The identification of genetic markers associated with oral cancer is considered essential to improve the diagnosis, prognosis, early tumor and relapse detection and, ultimately, to delineate individualized therapeutic approaches. Here, we aimed at identifying such markers.Multiplex Ligation-dependent Probe Amplification (MLPA) analyses encompassing 133 cancer-related genes were performed on a panel of primary oral tumor samples and its corresponding resection margins (macroscopically tumor-free tissue) allowing, in both types of tissue, the detection of a wide arrange of copy number imbalances on various human chromosomes.We found that in tumor tissue, from the 133 cancer-related genes included in this study, those that most frequently exhibited copy number gains were located on chromosomal arms 3q, 6p, 8q, 11q, 16p, 16q, 17p, 17q and 19q, whereas those most frequently exhibiting copy number losses were located on chromosomal arms 2q, 3p, 4q, 5q, 8p, 9p, 11q and 18q. Several imbalances were highlighted, i.e., losses of ERBB4, CTNNB1, NFKB1, IL2, IL12B, TUSC3, CDKN2A, CASP1, and gains of MME, BCL6, VEGF, PTK2, PTP4A3, RNF139, CCND1, FGF3, CTTN, MVP, CDH1, BRCA1, CDKN2D, BAX, as well as exon 4 of TP53. Comparisons between tumor and matched macroscopically tumor-free tissues allowed us to build a logistic regression model to predict the tissue type (benign versus malignant). In this model, the TUSC3 gene showed statistical significance, indicating that loss of this gene may serve as a good indicator of malignancy.Our results point towards relevance of the above mentioned cancer-related genes as putative genetic markers for oral cancer. For practical clinical purposes, these genetic markers should be validated in additional studies.
Starting Page	29
Ending Page	39
Page Count	11
File Format	PDF
ISSN	22113428
Journal	Cellular Oncology
Volume Number	37
Issue Number	1
e-ISSN	22113436
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-12-19
Publisher Institution	International Society for Cellular Oncology
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Oral squamous cell carcinoma Genetic profile Chromosomal imbalances Copy number losses and gains Cancer Research Biomedicine general Pathology Oncology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Molecular Medicine Oncology

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