NDLI: Genomic DNA copy number alterations from precursor oral lesions to oral squamous cell carcinoma.

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Genomic DNA copy number alterations from precursor oral lesions to oral squamous cell carcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Salahshourifar, Iman Vincent-Chong, Vui King Kallarakkal, Thomas George Zain, Rosnah Binti
Description	Country affiliation: Malaysia Author Affiliation: Salahshourifar I ( Oral Cancer Research and Coordinating Centre (OCRCC), Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.); Vincent-Chong VK ( Oral Cancer Research and Coordinating Centre (OCRCC), Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.); Kallarakkal TG ( Oral Cancer Research and Coordinating Centre (OCRCC), Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia); Zain RB ( Oral Cancer Research and Coordinating Centre (OCRCC), Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia)
Abstract	Oral cancer is a multifactorial disease in which both environmental and genetic factors contribute to the aetiopathogenesis. Oral cancer is the sixth most common cancer worldwide with a higher incidence among Melanesian and South Asian countries. More than 90% of oral cancers are oral squamous cell carcinoma (OSCC). The present study aimed to determine common genomic copy number alterations (CNAs) and their frequency by including 12 studies that have been conducted on OSCCs using array comparative genomic hybridization (aCGH). In addition, we reviewed the literature dealing with CNAs that drive oral precursor lesions to the invasive tumors. Results showed a sequential accumulation of genetic changes from oral precursor lesions to invasive tumors. With the disease progression, accumulation of genetic changes increases in terms of frequency, type and size of the abnormalities, even on different regions of the same chromosome. Gains in 3q (36.5%), 5p (23%), 7p (21%), 8q (47%), 11q (45%), 20q (31%) and losses in 3p (37%), 8p (18%), 9p (10%) and 18q (11%) were the most common observations among those studies. However, losses are less frequent than gains but it appears that they might be the primary clonal events in causing oral cancer.
File Format	HTM / HTML
ISSN	13688375
Issue Number	5
Volume Number	50
e-ISSN	18790593
Journal	Oral Oncology
Language	English
Publisher	Elsevier
Publisher Date	2014-05-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Oncology Carcinoma, Squamous Cell Genetics Dna Copy Number Variations Mouth Neoplasms Precancerous Conditions Pathology Disease Progression Humans Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Oral Surgery Cancer Research Oncology

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