NDLI: ELMO3 expression indicates a poor prognosis in head and neck squamous cell carcinoma

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ELMO3 expression indicates a poor prognosis in head and neck squamous cell carcinoma - a short report

Cellular Oncology : Volume 40, Issue 1, February 2017

Cellular Oncology : Volume 39

Cellular Oncology : Volume 38

Cellular Oncology : Volume 37

Cellular Oncology : Volume 36

Cellular Oncology : Volume 35

Cellular Oncology : Volume 34

ELMO3 expression indicates a poor prognosis in head and neck squamous cell carcinoma - a short report

Content Provider	Springer Nature Link
Author	Kadletz, Lorenz Heiduschka, Gregor Wiebringhaus, Robert Gurnhofer, Elisabeth Kotowski, Ulana Haymerle, Georg Brunner, Markus Barry, Conor Kenner, Lukas
Copyright Year	2016
Abstract	Previously, the engulfment and cell motility 3 (ELMO3) protein has been reported to be involved in cell migration and cytoskeletal remodeling. As of yet, nothing is known about the role of ELMO3 in head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to asses ELMO3 expression in postoperatively irradiated HNSCC patients and to evaluate a possible correlation between this expression and patient survival.125 postoperatively irradiated HNSCC patients were included in this study. ELMO3 expression was assessed using immunohistochemistry (IHC). The expression of ELMO3 in the respective HNSCC tumor tissues and its lymph node metastases was correlated with patient survival using Kaplan-Meier curve analyses.Through IHC, ELMO3 expression was detected in 71.2% of the HNSCC cases tested. We found significantly increased overall and disease-free survival rates and decreased recurrence rates in patients with no detectable ELMO3 expression. In reverse, we found that ELMO3 expression served as an independent marker for a decreased overall and disease-free survival.Our data indicate that in the surgically treated and postoperatively irradiated patients tested, ELMO3 expression serves as a predictive marker for reduced survival.
Starting Page	193
Ending Page	198
Page Count	6
File Format	PDF
ISSN	22113428
Journal	Cellular Oncology
Volume Number	40
Issue Number	2
e-ISSN	22113436
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-12-30
Publisher Institution	International Society for Cellular Oncology
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Head and neck Squamous cell carcinoma ELMO3 Prognosis Radiotherapy Postoperative irradiation Cancer Research Biomedicine Pathology Oncology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Molecular Medicine Oncology

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