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Increased interleukin-6 expression is associated with poor prognosis and acquired cisplatin resistance in head and neck squamous cell carcinoma.
| Content Provider | Europe PMC |
|---|---|
| Author | GAO, JIAN ZHAO, SEN HALSTENSEN, TROND S. |
| Copyright Year | 2016 |
| Abstract | Increased expression of interleukin 6 (IL-6) is associated with poor prognosis and chemoresistance in many different carcinomas, but its role in head and neck squamous cell carcinoma (HNSCC) is still unsettled. Analyzing tumorous mRNA expression data from 399 HNSCC patients revealed that high IL-6 expression predicted poor prognosis. Similar tendency was observed in platinum treated patients, suggesting an IL-6 associated cisplatin resistance. IL-6 increase was also found in two in-house acquired cisplatin-resistant HNSCC cell lines (both basaloid and conventional squamous cell carcinoma) by using microarray analysis. However, although the in-house acquired cisplatin-resistant cell lines had higher basal and markedly increased cisplatin-induced IL-6 expression, IL-6 did not mediate the cisplatin resistance as neither exogenous IL-6 nor IL-6R/gp130 inhibitors affected cisplatin sensitivity. Moreover, the IL-6/STAT3 pathway was impaired in the resistant cell lines, partly due to decreased IL-6R expression. Thus, high IL-6 expression correlated to poor prognosis and acquired cisplatin resistance, but it did not mediate cisplatin resistance in the HNSCC cell lines. |
| ISSN | 1021335X |
| Journal | Oncology Reports |
| Volume Number | 35 |
| PubMed Central reference number | PMC4869939 |
| Issue Number | 6 |
| PubMed reference number | 27108527 |
| e-ISSN | 17912431 |
| DOI | 10.3892/or.2016.4765 |
| Language | English |
| Publisher | D.A. Spandidos |
| Publisher Date | 2016-04-20 |
| Access Restriction | Open |
| Rights License | This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Copyright: © Gao et al. |
| Subject Keyword | interleukin-6 head and neck squamous cell carcinoma prognosis cisplatin resistance |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
