NDLI: In vitro hemorheological effects of parenteral agents used in peripheral arterial disease

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Korea-Australia Rheology Journal : Volume 26, Issue 1, February 2014

Korea-Australia Rheology Journal : Volume 25

Korea-Australia Rheology Journal : Volume 24

Korea-Australia Rheology Journal : Volume 23

In vitro hemorheological effects of parenteral agents used in peripheral arterial disease

Content Provider	Springer Nature Link
Author	Biro, Katalin Sandor, Barbara Toth, Andras Koltai, Katalin Papp, Judit Rabai, Miklos Toth, Kalman Kesmarky, Gabor
Copyright Year	2014
Abstract	Peripheral arterial disease (PAD) is a frequent manifestation of systemic atherosclerosis. In PAD hemorheological parameters were defined as risk factors in a number of studies and several therapeutic agents were tried in these conditions. Our study aims to investigate and compare the in vitro hemorheological effects of various drugs generally used in the parenteral treatment of intermittent claudication and critical limb ischemia. Blood samples of healthy male volunteers were incubated with iloprost, alprostadil, pentoxifylline, sulodexide or pentosan polysulfate at calculated therapeutic serum concentration. Hematocrit (Hct) was determined by microhematocrit centrifuge. Plasma and apparent whole blood viscosities (WBV) were evaluated by capillary viscometer. Red blood cell aggregation was measured by LORCA (laserassisted optical rotational cell analyzer) aggregometer, and LORCA ektacytometer was used for measuring erythrocyte deformability at 37°C. Iloprost, alprostadil, and pentoxifylline incubation did not have any significant effect on plasma and apparent WBV. Elongation index increased in samples incubated with alprostadil at low shear stresses 0.95 and 0.53 Pa (p < 0.05). Sulodexide significantly improved WBV and Hct/WBV ratio (p < 0.05). Incubation with pentosan polysulfate resulted in higher WBV, lower Hct/WBV ratio and deterioration in the aggregation parameters (p < 0.05). Sulodexide may have beneficial effect on a macrorheological parameter; alprostadil may improve a microrheological parameter. Hemorheological alterations could be important in PAD patients with hampered vasodilator capacity.
Starting Page	243
Ending Page	247
Page Count	5
File Format	PDF
ISSN	1226119X
Journal	Korea-Australia Rheology Journal
Volume Number	26
Issue Number	2
e-ISSN	20937660
Language	English
Publisher	Korean Society of Rheology, Australian Society of Rheology
Publisher Date	2014-06-01
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	peripheral arterial disease plasma and whole blood viscosity red blood cell aggregation elongation index in vitro study Characterization and Evaluation of Materials Polymer Sciences Soft and Granular Matter, Complex Fluids and Microfluidics Mechanical Engineering Food Science
Content Type	Text
Resource Type	Article
Subject	Condensed Matter Physics Materials Science

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In vitro hemorheological effects of parenteral agents used in peripheral arterial disease

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Hemorheological changes and hematometric erythrocyte characteristics in rats after sodium nitrite intoxication

Blood rheology in shear and uniaxial elongation

Red blood cell aggregation parameters measured by capillary tube aggregometer using venous and capillary blood samples

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In vitro hemorheological effects of parenteral agents used in peripheral arterial disease

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