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Regional areas and widths of the midsagittal corpus callosum among HIV-infected patients on stable antiretroviral therapies

Content Provider	Springer Nature Link
Author	Tate, David F. Sampat, Mehul Harezlak, Jaroslaw Fiecas, Mark Hogan, Joseph Dewey, Jeffrey McCaffrey, Daniel Branson, Daniel Russell, Troy Conley, Jared Taylor, Michael Schifitto, Giavoni Zhong, J. Daar, Eric S. Alger, Jeffrey Brown, Mark Singer, Elyse Campbell, T. McMahon, D. Tso, Y. Matesan, Janetta Letendre, Scott Paulose, S. Gaugh, Michelle Tripoli, C. Yiannoutsos, Constantine Bigler, Erin D. Cohen, Ronald A. Guttmann, Charles R. G. Navia, Bradford
Copyright Year	2011
Abstract	Recent reports suggest that a growing number of human immunodeficiency virus (HIV)-infected persons show signs of persistent cognitive impairment even in the context of combination antiretroviral therapies (cART). The basis for this finding remains poorly understood as there are only a limited number of studies examining the relationship between CNS injury, measures of disease severity, and cognitive function in the setting of stable disease. This study examined the effects of HIV infection on cerebral white matter using quantitative morphometry of the midsagittal corpus callosum (CC) in 216 chronically infected participants from the multisite HIV Neuroimaging Consortium study currently receiving cART and 139 controls. All participants underwent MRI assessment, and HIV-infected subjects also underwent measures of cognitive function and disease severity. The midsagittal slice of the CC was quantified using two semi-automated procedures. Group comparisons were accomplished using ANOVA, and the relationship between CC morphometry and clinical covariates (current CD4, nadir CD4, plasma and CSF HIV RNA, duration of HIV infection, age, and ADC stage) was assessed using linear regression models. HIV-infected patients showed significant reductions in both the area and linear widths for several regions of the CC. Significant relationships were found with ADC stage and nadir CD4 cell count, but no other clinical variables. Despite effective treatment, significant and possibly irreversible structural loss of the white matter persists in the setting of chronic HIV disease. A history of advanced immune suppression is a strong predictor of this complication and suggests that antiretroviral intervention at earlier stages of infection may be warranted.
Starting Page	368
Ending Page	379
Page Count	12
File Format	PDF
ISSN	13550284
Journal	Journal of NeuroVirology
Volume Number	17
Issue Number	4
e-ISSN	15382443
Language	English
Publisher	Springer US
Publisher Date	2011-05-10
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	HIV Corpus callosum Nadir CD4 White matter CART Infectious Diseases Virology Immunology Neurosciences Neurology
Content Type	Text
Resource Type	Article
Subject	Neurology Virology Neurology (clinical) Cellular and Molecular Neuroscience

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Erratum to: Regional areas and widths of the midsagittal corpus callosum among HIV-infected patients on stable antiretroviral therapies

Erratum to: Regional areas and widths of the midsagittal corpus callosum among HIV-infected patients on stable antiretroviral therapies

Regional areas and widths of the midsagittal corpus callosum among HIV-infected patients on stable antiretroviral therapies

Early suppressive antiretroviral therapy in HIV infection is associated with measurable changes in the corpus callosum

Effects of nadir CD4 count and duration of human immunodeficiency virus infection on brain volumes in the highly active antiretroviral therapy era

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Predictors of CNS injury as measured by proton magnetic resonance spectroscopy in the setting of chronic HIV infection and CART

Subtype associations with HIV-associated neurocognitive disorder in China

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Regional areas and widths of the midsagittal corpus callosum among HIV-infected patients on stable antiretroviral therapies

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