NDLI: Clinical symptoms and the odds of human T-cell lymphotropic virus type 1-associated myelopathy/ tropical spastic paraparesis (HAM/TSP) in healthy virus carriers: Application of best-fit logistic regression equation based on host genotype, age, and provirus load

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Clinical symptoms and the odds of human T-cell lymphotropic virus type 1-associated myelopathy/ tropical spastic paraparesis (HAM/TSP) in healthy virus carriers: Application of best-fit logistic regression equation based on host genotype, age, and provirus load

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Journal of NeuroVirology : Volume 12, Issue 2, March 2006

Journal of NeuroVirology : Volume 12, Issue 1, Supplement,January 2006

Journal of NeuroVirology : Volume 12, Issue 1, January 2006

Journal of NeuroVirology : Volume 11

Journal of NeuroVirology : Volume 10

Journal of NeuroVirology : Volume 9

Journal of NeuroVirology : Volume 8

Journal of NeuroVirology : Volume 7

Clinical symptoms and the odds of human T-cell lymphotropic virus type 1-associated myelopathy/ tropical spastic paraparesis (HAM/TSP) in healthy virus carriers: Application of best-fit logistic regression equation based on host genotype, age, and provirus load

Content Provider	Springer Nature Link
Author	Nose, Hirohisa Saito, Mineki Usuku, Koichiro Sabouri, Amir H. Matsuzaki, Toshio Kubota, Ryuji Eiraku, Nobutaka Furukawa, Yoshitaka Izumo, Shuji Arimura, Kimiyoshi Osame, Mitsuhiro
Copyright Year	2006
Abstract	The authors have previously developed a logistic regression equation to predict the odds that a human T-cell lymphotropic virus type 1 (HTLV-1)-infected individual of specified genotype, age, and provirus load has HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in southern Japan. This study evaluated whether this equation is useful predictor for monitoring asymptomatic HTLV-1-seropositive carriers (HCs) in the same population. The authors genotyped 181 HCs for each HAM/TSP-associated gene (tumor necrosis factor [TNF]-α −863A/C, stromal cell-derived factor 1 (SDF-1) +801G/A, human leukocyte antigen [HLA]-A02, HLA-Cw08, HTLV-1 tax subgroup) and measured HTLV-1 provirus load in peripheral blood mononuclear cells using real-time polymerase chain reaction (PCR). Finally, the odds of HAM/TSP for each subject were calculated by using the equation and compared the results with clinical symptoms and laboratory findings. Although no clear difference was seen between the odds of HAM/TSP and either sex, family history of HAM/TSP or adult T-cell lenkemia (ATL), history of blood transfusion, it was found that brisk patellar deep tendon reflexes, which suggest latent central nervous system compromise, and flower cell-like abnormal lymphocytes, which is the morphological characteristic of ATL cells, were associated with a higher odds of HAM/TSP. The bestfit logistic regression equation may be useful for detecting subclinical abnormalities in HCs in southern Japan.
Starting Page	171
Ending Page	177
Page Count	7
File Format	PDF
ISSN	13550284
Journal	Journal of NeuroVirology
Volume Number	12
Issue Number	3
e-ISSN	15382443
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	best-fit logistic regression equation clinical symptoms HAM/TSP HTLV-1 HTLV-1 carriers Neurosciences Virology Infectious Diseases Immunology Neurology
Content Type	Text
Resource Type	Article
Subject	Neurology Virology Neurology (clinical) Cellular and Molecular Neuroscience

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HTLV-1 proviral integration sites differ between asymptomatic carriers and patients with HAM/TSP

Pathological mechanisms of human T-cell lymphotropic virus type I-associated myelopathy (HAM/TSP)

Deep sequencing analysis of Human T cell lymphotropic virus type 1 (HTLV-1) long terminal repeat (LTR) region of tropical spastic paraparesis (TSP)/HTLV-1 associated myelopathy (HAM) and asymptomatic carriers

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Deep sequencing analysis of Human T cell lymphotropic virus type 1 (HTLV-1) long terminal repeat (LTR) region of tropical spastic paraparesis (TSP)/HTLV-1 associated myelopathy (HAM) and asymptomatic carriers

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Clinical symptoms and the odds of human T-cell lymphotropic virus type 1-associated myelopathy/ tropical spastic paraparesis (HAM/TSP) in healthy virus carriers: Application of best-fit logistic regression equation based on host genotype, age, and provirus load

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