NDLI: Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels

Content Provider	Springer Nature Link
Author	Miotke, M. Strankowska, J. Kwela, J. Strankowski, M. Piszczyk, Ł. Józefowicz, M. Gazda, M.
Copyright Year	2017
Abstract	Studies of swelling and release of naproxen sodium (NAP) solution by polyurethane nanocomposite hydrogels containing Cloisite® 30B (organically modified montmorillonite (OMMT)) have been performed. Polyurethane nanocomposite hydrogels are hybrid, nontoxic biomaterials with unique swelling and release properties in comparison with unmodified hydrogels. These features enable to use nanocomposite hydrogels as a modern wound dressing. The presence of nanoparticles significantly improves the swelling. On the other hand, their presence hinders drug diffusion from polymer matrix and consequently causes delay of the drug release. The kinetics of swelling and release were carefully analyzed using the Korsmeyer-Peppas and the modified Hopfenberg models. The models were fitted to precise experimental data allowing accurate quantitative and qualitative analysis. We observed that 0.5% admixture of nanoparticles (Cloisite® 30B) is the best concentration for hydrogel swelling properties. The release process was studied using fluorescence excitation spectra of NAP. Furthermore, we studied swelling hysteresis; polymer chains have not been destroyed after the swelling and part of swelled solution with active substances which remained absorbed in the polymer matrix after the drying process. We have found that the amount of solution with NAP remained in the nanocomposite matrix is greater than in pure hydrogel, as a consequence of NAP-OMMT interactions (nanosize effect).
Starting Page	1
Ending Page	15
Page Count	15
File Format	PDF
Journal	The European Physical Journal Plus
Volume Number	132
Issue Number	9
e-ISSN	21905444
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2017-09-25
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Applied and Technical Physics Theoretical, Mathematical and Computational Physics Complex Systems Condensed Matter Physics Atomic, Molecular, Optical and Plasma Physics
Content Type	Text
Resource Type	Article

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