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Overview of computational vaccinology: vaccine development through information technology

Content Provider	Springer Nature Link
Author	Vaishnav, Nishita Gupta, Aparna Paul, Sneha John, Georrge J.
Copyright Year	2014
Abstract	Pathogenic organisms, causes of various infectious diseases, possess a rich repository of antigenic proteins that engender an immune response in a host. These types of diseases are usually treated with the use of pharmaceuticals; unfortunately, many of these also have a potential to induce fatal side effects, especially allergic responses in the diseased host. In addition, many pathogens evolve (by selective survival) single or multi-drug resistance (MDR). Therefore, a means to prevent the host from becoming susceptible to the pathogen from the onset, rather than trying to devise pharmacologic protocols to treat an ongoing infection, are increasingly seen as desirable to reduce the incidence of infectious diseases altogether. To this end, cost-effective development and use of “safe” vaccines is key. This paper provides an overview on the new and expanding area of computational vaccinology and a brief background on pathogen antigenicity, identification of pathogen-specific antigens, and screening of candidate antigens using various tools and databases developed in the recent past.
Starting Page	381
Ending Page	391
Page Count	11
File Format	PDF
ISSN	12341983
Journal	Journal of Applied Genetics
Volume Number	56
Issue Number	3
e-ISSN	21903883
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-12-23
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Infection In silico Prediction Vaccine Life Sciences Animal Genetics and Genomics Human Genetics Microbial Genetics and Genomics Plant Genetics & Genomics
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine

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Overview of computational vaccinology: vaccine development through information technology.

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Overview of computational vaccinology: vaccine development through information technology.

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