NDLI: The retinal fascin gene 2 (FSCN2) — partial structural analysis and polymorphism detection in dogs with progressive retinal atrophy (PRA)

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The retinal fascin gene 2 (FSCN2) — partial structural analysis and polymorphism detection in dogs with progressive retinal atrophy (PRA)

Content Provider	Springer Nature Link
Author	Horák, Pavel Knoll, Aleš Dvořák, Josef
Copyright Year	2006
Abstract	The retinal fascin 2 gene (FSCN2) underwent a molecular analysis, a search for polymorphisms and an evaluation as a candidate gene for retinopathies in dogs. Specific fragments of the gene encompassing partial exon 1 and intron 1, and exons 2–5 with respective introns were sequenced and these data were deposited in the GenBank database. Three distinct polymorphic sites detectable with PCR-RFLP were found — AM050719: g.237G > A, AM050719: g.525A > G, and AM050720: g. 1071A > G. No positive associations between these polymorphisms and the PRA-clinical status were observed in the investigated population consisting of Poodles, American Cocker Spaniels, and English Cocker Spaniels. In spite of that, theFSCN2 gene remains an excellent candidate gene for retinopathies in dogs and the results can contribute to further research in this field.
Starting Page	361
Ending Page	364
Page Count	4
File Format	PDF
ISSN	12341983
Journal	Journal of Applied Genetics
Volume Number	47
Issue Number	4
e-ISSN	21903883
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-01-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Canis familiaris FSCN2 gene PCR-RFLP PRA Life Sciences Animal Genetics and Genomics Human Genetics Microbial Genetics and Genomics Plant Genetics & Genomics
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine

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