NDLI: High expression of TRIM44 is associated with enhanced cell proliferation, migration, invasion, and resistance to doxorubicin in hepatocellular carcinoma

Content Provider	Springer Nature Link
Author	Zhu, Xinghua Wu, Yaxun Miao, Xiaobing Li, Chunsun Yin, Haibing Yang, Shuyun Lu, Xiaoyun Liu, Yushan Chen, Yali Shen, Rong Chen, Xudong He, Song
Copyright Year	2016
Abstract	Dysregulation of TRIM44 has been reported to be involved in tumorigenesis, but its role in hepatocellular carcinoma (HCC) remains unclear. In the present study, we investigated the clinicopathological and biological significance of TRIM44 in HCC. We found that TRIM44 mRNA and protein expression was upregulated in HCC compared with matched normal tissues. Intriguingly, we also found that TRIM44 expression was significantly correlated with tumor size (P < 0.001), vascular invasion (P < 0.001), intrahepatic metastasis (P < 0.001), distant metastasis (P < 0.001), and Ki-67 expression (P < 0.001). Kaplan-Meier analysis showed that high TRIM44 staining was significantly correlated with shorter overall survival (P < 0.001). TRIM44 was an independent predictor of overall survival in patients with HCC. Furthermore, we found that ectopic expression of TRIM44 could promote cell proliferation via accelerating the G1/S-phase transition in HCC. Moreover, overexpression of TRIM44 could enhance the invasive and migratory capacity of HCC cells. Meanwhile, we found that high expression of TRIM44 could enhance resistance of HCC cells to doxorubicin via accelerating NF-κB activation. In conclusion, our results suggest that TRIM44 may be a novel prognostic indicator and potential therapeutic target of HCC.
Starting Page	14615
Ending Page	14628
Page Count	14
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	37
Issue Number	11
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-09-12
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	TRIM44 Hepatocellular carcinoma (HCC) Cell proliferation Migration Invasion Drug resistance Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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