NDLI: Hepatitis B virus X protein reduces the stability of Nrdp1 to up-regulate ErbB3 in hepatocellular carcinoma cells

Content Provider	Springer Nature Link
Author	Cao, Kuan Gong, Hui Qiu, Zhichao Wen, Quan Zhang, Bin Tang, Tianjin Zhou, Xinyu Cao, Tong Wang, Bin Shi, Hengliang Wang, Renhao
Copyright Year	2016
Abstract	Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) is the most widespread type of liver cancer. However, the underlying mechanism of HCC tumorigenesis is very intricate and HBV-encoded X protein (HBx) has been reported to play a key role in this process. It has been reported that HBx up-regulates the transcription of ErbB3. However, it remains unclear whether HBx can regulate ErbB3 expression at post-translational modification level. In this study, we showed that HBx interacts with ubiquitin ligase Nrdp1 (neuregulin receptor degradation protein 1) and decreases its stability, which results in the up-regulation of ErbB3 and promotion of HCC cells. Moreover, the expression of ErbB3 was almost undetectable in normal liver tissues but was relative abundant in HCC tissues, and the level of ErbB3 and Nrdp1 significantly showed a negative correlation in HCC tissues. Taken together, these findings suggest that HBx promotes the progression of HCC by decreasing the stability of Nrdp1, which results in up-regulation of ErbB3, suggesting that ErbB3 may be a target for HCC therapy.
Starting Page	10375
Ending Page	10382
Page Count	8
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	37
Issue Number	8
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-02-04
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	HBV HBx ErbB3 Nrdp1 HCC Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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