NDLI: P21-Activated kinase 5 affects cisplatin-induced apoptosis and proliferation in hepatocellular carcinoma cells

Content Provider	Springer Nature Link
Author	Zhang, Ding Guo Zhang, Jinling Mao, Lin Lin Wu, Jin Xia Cao, Wen Jia Zheng, Jun Nian Pei, Dong Sheng
Copyright Year	2015
Abstract	p21-Activated kinase 5 (PAK5) is the last identified member of the PAK family. The PAKs are highly conserved serine/threonine and effector proteins for Cdc42 and Rac and are essential in regulating cell motility and survival. Previous studies have demonstrated that PAK5 played a pivotal role in apoptosis, proliferation, cancer migration, and invasion. However, the biological function of PAK5 in hepatocellular carcinoma, as well as its underlying mechanism, still remains to be fully elucidated. In the present study, we demonstrated that PAK5 markedly inhibited cisplatin-induced apoptosis and promoted cell proliferation in hepatocellular carcinoma cells. Moreover, our results showed that overexpression of PAK5 contributed to cell cycle regulation. In order to elucidate the underlying mechanism of PAK5 on cisplatin-induced apoptosis and cell cycle regulation, we also examined the protein expressions of chk2 and p-chk2. In summary, our study investigated the role of PAK5 in cisplatin-induced cellular processes and provided evidence of its underlying mechanism.
Starting Page	3685
Ending Page	3691
Page Count	7
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	36
Issue Number	5
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-01-07
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	p21-Activated kinase 5 Apoptosis Cell cycle arrest p-chk2 Cisplatin Hepatocellular carcinoma Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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