NDLI: Plasma D-dimer value as a predictor of malignant lymph node involvement in operable non-small cell lung cancer

Content Provider	Springer Nature Link
Author	Chen, Feng Wang, Min Jie Li, Jia Yan, Cui E Han, Xiao Hong Wu, Zong Yong Qi, Jun
Copyright Year	2015
Abstract	Fibrin deposition and remodelling of the extracellular matrix are important early steps in tumour metastasis. The D-dimer value is an indicator of intravascular fibrin formation and degradation. Thus, the D-dimer value may be a predictor of the malignant involvement of lymph nodes in operable non-small cell lung cancer (NSCLC) patients. The study comprised 142 highly suspected lung cancer patients scheduled to undergo pneumonectomy, lobectomy or wedge resection. Of the 142 patients, 124 were subsequently diagnosed as NSCLC, and 18 were subsequently diagnosed as benign lung disease by histological examination. Preoperative plasma D-dimer values were quantified, and the relationship between plasma D-dimer and clinical variables including tumour size, involvement of lymph nodes and clinical stage was examined using Spearman correlation coefficients and χ $^{2}$ tests. The median plasma D-dimer values were statistically higher in NSCLC patients with malignant lymph nodes than in those who suffered either benign lung disease or carcinoma in situ (Kruskal–Wallis test; P = 0.001). Plasma D-dimer values were significantly correlated with clinical stage (ANOVA; P = 0.009). An obvious relationship was observed between elevated D-dimer (>0.475 mg/L fibrinogen equivalent units) and malignant lymph node involvement (χ $^{2}$ test; P = 0.0000). This correlation suggests that the plasma D-dimer value is a clinically important predictor for the malignant involvement of lymph nodes in operable NSCLC.
Starting Page	9201
Ending Page	9207
Page Count	7
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	36
Issue Number	12
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-06-19
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	D-dimer Non-small cell lung cancer Lymph node Metastasis Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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