NDLI: Extracellular vesicles from women with breast cancer promote an epithelial-mesenchymal transition-like process in mammary epithelial cells MCF10A

Content Provider	Springer Nature Link
Author	Galindo Hernandez, Octavio Gonzales Vazquez, Cristina Cortes Reynosa, Pedro Reyes Uribe, Emmanuel Chavez Ocaña, Sonia Reyes Hernandez, Octavio Sierra Martinez, Mónica Salazar, Eduardo Perez
Copyright Year	2015
Abstract	Extracellular vesicles (EVs) mediate many stages of tumor progression including angiogenesis, escape from immune surveillance, and extracellular matrix degradation. We studied whether EVs from plasma of women with breast cancer are able to induce an epithelial-mesenchymal transition (EMT) process in mammary epithelial cells MCF10A. Our findings demonstrate that EVs from plasma of breast cancer patients induce a downregulation of E-cadherin expression and an increase of vimentin and N-cadherin expression. Moreover, EVs induce migration and invasion, as well as an increase of NFκB-DNA binding activity and MMP-2 and MMP-9 secretions. In summary, our findings demonstrate, for the first time, that EVs from breast cancer patients induce an EMT-like process in human mammary non-tumorigenic epithelial cells MCF10A.
Starting Page	9649
Ending Page	9659
Page Count	11
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	36
Issue Number	12
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-07-07
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Extracellular vesicles Breast cancer EMT MCF10A Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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