NDLI: Significant association among the Fas -670 A/G (rs1800682) polymorphism and esophageal cancer, hepatocellular carcinoma, and prostate cancer susceptibility: a meta-analysis

Content Provider	Springer Nature Link
Author	Liu, Tao Zuo, Li Li, Lin Yin, Lei Liang, Kai Yu, Hongyuan Ren, Hui Zhou, Wen Jing, Hongwei Liu, Yang Kong, Chuize
Copyright Year	2014
Abstract	The Fas gene plays a key role in regulation of apoptotic cell death, and corruption of this signaling pathway has been shown to participate in immune escape and tumorgenesis. Single-nucleotide polymorphism in the promoter of Fas gene at position -670 A/G may affect its expression and play an important role in the pathology of many kinds of cancer. The association between Fas -670 A/G polymorphism and cancer risk is still controversial and ambiguous. Therefore, we conducted a meta-analysis of the currently literature to clarify this relationship. We conducted a search in the PubMed, EMbase, CNKI, and WanFang databases, covering all papers published by May 5, 2014. Overall, 59 case–control studies with 17,035 cases and 23,155 controls were retrieved based on the search criteria for cancer susceptibility related to -670 A/G polymorphism in Fas gene. Odds ratios (OR) and 95 % confidence intervals (CI) revealed association strengths. Although no significant relationship was detected between Fas -670 A/G polymorphism and whole cancer risk, in the ethnicity subgroup, significant associations were found in three types of cancer: prostate cancer (OR = 1.06, 95 % CI = 1.01–1.11 for A-allele vs. G-allele); hepatocellular carcinoma (OR = 0.89, 95 % CI = 0.80–0.99 for AG vs. GG); esophageal cancer (OR = 0.95, 95 % CI = 0.92–0.99 for AA + AG vs. GG). Moreover, lower cancer risk was found in smokers carried A-allele, when compared to smokers carried the GG genotype. The Fas -670 A/G polymorphism may be associated with esophageal cancer, hepatocellular carcinoma, and prostate cancer susceptibility from our meta-analysis. Studies with larger samples and gene–environment interactions are warranted to understand the role of Fas -670 A/G polymorphism for cancer risk.
Starting Page	10911
Ending Page	10918
Page Count	8
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	35
Issue Number	11
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-08-02
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Fas -670 A/G Esophageal cancer Hepatocellular carcinoma Prostate cancer Smoking Meta-analysis Polymorphism Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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