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| Content Provider | Springer Nature Link |
|---|---|
| Author | Jung, Woo Young Seo, Dong Won Choi, Nu Ri Lee, Jun Heon Jin, Dong Il Hwang, Seong Soo Yang, Byoung Chul Chung, Hak Jae Kim, Kyung Woon Park, Jin Ki Lee, Hwi Cheul |
| Copyright Year | 2012 |
| Abstract | Xenotransplantation involves the transplantation of organs, tissues and cells from one species to another. A major barrier to successful xenotransplantation is the rejection of the donor tissue by the recipient immune system. Swine leukocyte antigens (SLA) are important molecules within the immune system and play an essential role in fighting infectious diseases and viruses. The present study investigated three SLA class I (SLA-1, SLA-3 and SLA-2) and three SLA class II (DRB1, DQB1 and DQA) alleles in 60 NIH miniature pigs using PCR with sequence-specific primers (PCR-SSP). As the results, nine combinations of SLA class I and II haplotypes, comprising of three homozygous and six heterozygous haplotypes, were examined. The SLA homozygous haplotype Lr-2.4/2.4 was the most prevalent, with an overall frequency of 28.3% (17/60) and heterozygous haplotype Lr-2.2/4.4 was the second most common (20.0%; 12/60), followed by haplotype Lr-4.2/4.2 (16.7%; 10/60), Lr-2.2/2.4 (15.0%; 9/60), Lr-2.2/2.2 (5.0%; 3/60), Lr-2.2/4.2 (5.0%; 3/60), Lr-2.4/4.4 (5.0%; 3/60) and Lr-2.2/3.3 (3.3%; 2/60), Lr-4.2/4.4 (1.7%; 1/60), respectively. These results provide useful information that can be used to establish highly inbred pig lines with fixed SLA homozygous alleles and haplotypes. |
| Starting Page | 429 |
| Ending Page | 434 |
| Page Count | 6 |
| File Format | |
| ISSN | 19769571 |
| Journal | Genes & Genomics |
| Volume Number | 34 |
| Issue Number | 4 |
| e-ISSN | 20929293 |
| Language | English |
| Publisher | The Genetics Society of Korea |
| Publisher Date | 2012-08-13 |
| Publisher Place | Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Haplotype Miniature pigs NIH Xenotransplantation PCR-SSP Swine leukocyte antigen (SLA) Plant Genetics & Genomics Human Genetics Microbial Genetics and Genomics Animal Genetics and Genomics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Biochemistry Molecular Biology |
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