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| Content Provider | Springer Nature Link |
|---|---|
| Author | Moon, Jae Woo Ahn, Kung Bae, Jin Han Nam, Gyu Hwi Cho, Byung Wook Park, Kyung Do Lee, Hak Kyo Yang, Young Mok Kim, Tae Hun Seong, Hwan Hoo Han, Kyudong Kim, Heui Soo |
| Copyright Year | 2012 |
| Abstract | Cartilage increases flexibility of motion and helps protect the body from physical shock. Strong physical shock or some biological factor could cause joint disease. ADAMTS4 (a disintegrin and metalloproteinase with thrombospondin motifs 4) has been related to degradation of aggrecans in cartilage. It has been associated with joint disease, which could influence the ability of horses to exercise. Here, we performed sequence analysis and expression profiling of the ADAMTS4 gene in thoroughbred horses. Quantitative real-time RT-PCR data indicated that higher expression of the ADAMTS4 gene appeared in the cartilage tissues compared to those of pancreas, stomach, lung and colon. The expression pattern was also higher in the muscle tissues after exercise than before exercise. These data could be of great use for further studies in relation to both horse racing and joint disease. |
| Starting Page | 441 |
| Ending Page | 445 |
| Page Count | 5 |
| File Format | |
| ISSN | 19769571 |
| Journal | Genes & Genomics |
| Volume Number | 34 |
| Issue Number | 4 |
| e-ISSN | 20929293 |
| Language | English |
| Publisher | The Genetics Society of Korea |
| Publisher Date | 2012-08-13 |
| Publisher Place | Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | ADAMTS4 gene Expression Muscle tissues, Quantitative real-time RT-PCR Thoroughbred horse Plant Genetics & Genomics Human Genetics Microbial Genetics and Genomics Animal Genetics and Genomics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Biochemistry Molecular Biology |
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