NDLI: Surfactant-free nanoparticles of doxorubicin-conjugated poly(DL-lactide-co-glycolide)

Content Provider	Springer Nature Link
Author	Vu, Manh Tuan Jeong, Young IL Choi, Changyong Nam, Joung Pyo Son, Dong Hee Park, Jun Kyu Kim, Won Seok Kim, Myung Yul Jang, Mi Kyeong Nah, Jae Woon Kim, Kwang Jae
Copyright Year	2010
Abstract	Doxorubicin (DOX)-conjugated poly(DL-lactide-co-glycolide)(PLGA) was synthesized and nanoparticles were prepared without the use of a surfactant. The DOX content in the nanoparticles ranged from 1.2 to 4.75% (w/w). The particle size of the DOX-conjugated PLGA (DOX-LG) nanoparticles increased when a higher molecular weight (M.W.) of polymer was used. TEM revealed the nanoparticles to have spherical shapes with a size of approximately 100∼200 nm. The drug was released continuously from the nanoparticles over a one month period. In particular, the overall drug release from the nanoparticles prepared with a higher M.W. was significantly faster than that from nanoparticles with a lower M.W. The cytotoxicity test in vitro using CT26 colon carcinoma cells showed that the free DOX had higher cytotoxicity than DOX-LG. These results suggest that DOX was released slowly from nanoparticles and was exposed to the tumor cells. Moreover, DOX-LG might show low cytotoxicity due to these properties of nanoparticles.
Starting Page	1115
Ending Page	1120
Page Count	6
File Format	PDF
ISSN	15985032
Journal	Macromolecular Research
Volume Number	18
Issue Number	11
e-ISSN	20927673
Language	English
Publisher	The Polymer Society of Korea
Publisher Date	2010-11-26
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	doxorubicin surfactant-free nanoparticles poly(DL-lactide-co-glycolide) nanoprecipitation CT26 colon carcinoma cell Nanotechnology Nanochemistry Characterization and Evaluation of Materials Physical Chemistry Soft and Granular Matter, Complex Fluids and Microfluidics Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Materials Chemistry Chemical Engineering Polymers and Plastics

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