NDLI: Acidic pH-stimulated tiotropium release from porous poly(lactic-co-glycolic acid) microparticles containing 3-diethylaminopropyl-conjugated hyaluronate

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Acidic pH-stimulated tiotropium release from porous poly(lactic-co-glycolic acid) microparticles containing 3-diethylaminopropyl-conjugated hyaluronate

Content Provider	Springer Nature Link
Author	Kim, Sol Kwag, Dong Sup Lee, Dong Jin Lee, Eun Seong
Copyright Year	2016
Abstract	In this study, we developed porous poly(lactide-co-glycolide) (PLGA) microparticles (PM) exhibiting pH-activated drug release properties. The PMs were prepared via the water-in-oil-in-water (W$_{1}$/O/W$_{2}$) multi-emulsion method using PLGA, 3-diethylaminopropyl amine (DEAP)-conjugated hyaluronate (HA) (HA-DEAP), and an anti-cholinergic model drug (tiotropium). Here, HA-DEAP was incorporated into the PMs; it acted as a drug release activator, accelerating drug release. In vitro drug release studies revealed that the tiotropium was released from the PMs as their pores were destabilized by eletrostatic interactions between the carboxyl groups (negatively charged) of the HA molecules and the tertiary amine groups (positively charged) of the DEAP moieties under acidic environments. This PLGA microparticle system, which contains a HA-DEAP, could provide unique advantages in treating chronic obstructive pulmonary disease (COPD) with chronic respiratory acidosis.
Starting Page	176
Ending Page	181
Page Count	6
File Format	PDF
ISSN	15985032
Journal	Macromolecular Research
Volume Number	24
Issue Number	2
e-ISSN	20927673
Language	English
Publisher	The Polymer Society of Korea
Publisher Date	2016-01-05
Publisher Place	Seoul
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	porous microparticles poly(lactide-co-glycolide) tiotropium 3-diethylaminopropyl respiratory acidosis Polymer Sciences Soft and Granular Matter, Complex Fluids and Microfluidics Physical Chemistry Characterization and Evaluation of Materials Nanochemistry Nanotechnology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Materials Chemistry Chemical Engineering Polymers and Plastics

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