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| Content Provider | Springer Nature Link |
|---|---|
| Author | Duan, Qiangde Nandre, Rahul Zhou, Mingxu Zhu, Guoqiang |
| Copyright Year | 2017 |
| Abstract | Type I fimbriae commonly expressed by Escherichia coli mediate initial attachment of bacteria to host epithelial cells. However, the role of type I fimbriae in the adherence of porcine enterotoxigenic E. coli (ETEC) to host receptors is unclear. In this study, we examined the role of type I fimbriae in the adherence and biofilm formation of F18ac+ ETEC by constructing mutant strains with deletion of type I fimbrial major subunit (fimA) or minor subunit (fimH). The data indicated that the isogenic ΔfimA and ΔfimH mutants showed significantly lower adherence to porcine epithelial IPEC-1 and IPEC-J2 cells as compared to the F18ac+ ETEC parent strain. In addition, the adherence of F18ac+ ETEC to both cell lines was blocked by the presence of 0.5% D-mannose in the cell culture medium. In addition, both mutant strains impaired their ability to form biofilm in vitro. Interestingly, the deletion of fimA or fimH genes resulted in remarkable up-regulation of the expression of adhesin involved in diffuse adherence (AIDA-I). These results indicated that type I fimbriae may be required for efficient adherence of F18ac+ ETEC to pig epithelial cells and, perhaps, biofilm formation. |
| Starting Page | 793 |
| Ending Page | 799 |
| Page Count | 7 |
| File Format | |
| ISSN | 15904261 |
| Journal | Annals of Microbiology |
| Volume Number | 67 |
| Issue Number | 12 |
| e-ISSN | 18692044 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2017-10-24 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | Subscribed |
| Subject Keyword | F18ac+ ETEC Type I fimbriae Adherence Biofilm formation Microbiology Microbial Genetics and Genomics Microbial Ecology Mycology Medical Microbiology Applied Microbiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Applied Microbiology and Biotechnology |
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