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| Content Provider | Springer Nature Link |
|---|---|
| Author | Arafa, Manar Hamed Mohammad, Nanies Sameeh Atteia, Hebatallah Husseini Abd Elaziz, Hesham Radwan |
| Copyright Year | 2014 |
| Abstract | The possible effectiveness of resveratrol, a polyphenol present in different plants comprising berries, grapes and peanuts, on the prevention of doxorubicin-induced cardiac toxicity and fibrosis was investigated. Forty adult male Wistar albino rats were divided into four groups. Group I received normal saline, group II gavaged with resveratrol (20 mg/kg, daily for 4 weeks), group III received doxorubicin (2.5 mg/kg i.p. in six injections for 2 weeks; accumulative dose of 15 mg/kg), and group IV received doxorubicin + resveratrol (starting resveratrol intake 2 weeks before doxorubicin administration). Resveratrol significantly alleviated the increase in left ventricular lipid peroxidation, hydroxyproline, and tumor necrosis factor alpha levels as well as serum creatine kinase-myocardial band (CK-MB) activity and prevented the decrease in body and heart weights in doxorubicin-treated group. However, a marked protection against reduced glutathione content depletion and superoxide dismutase activity reduction was observed in the left ventricles of rats pretreated with resveratrol in combination with doxorubicin. Resveratrol also ameliorated the up-regulation of left ventricular caspase-3 and transforming growth factor-beta1 gene expression as well as left ventricular histopathological changes including necrosis and fibrosis induced by doxorubicin. Collectively, our results suggest that resveratrol provides a significant protection against doxorubicin-induced cardiotoxicity and fibrosis in rats. Therefore, it may be used as a promising cardioprotective agent in patients treated with doxorubicin due to malignant diseases. So, further clinical trials are required to confirm these findings. |
| Starting Page | 701 |
| Ending Page | 711 |
| Page Count | 11 |
| File Format | |
| ISSN | 11387548 |
| Journal | Journal of Physiology and Biochemistry |
| Volume Number | 70 |
| Issue Number | 3 |
| e-ISSN | 18778755 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2014-06-18 |
| Publisher Institution | University of Navarra, Spain |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Antioxidants Cardiotoxicity Doxorubicin Cardiac fibrosis Resveratrol Biomedicine general Human Physiology Animal Physiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Medicine Biochemistry |
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