NDLI: A Systematic and Meta-Analysis of Mortality in Experimental Mouse Models Analyzing Delayed Cerebral Ischemia After Subarachnoid Hemorrhage

Please wait, while we are loading the content...

Long-Term Effect of Participation in an Early Exercise and Education Program on Clinical Outcomes and Cost Implications, in Patients with TIA and Minor, Non-Disabling Stroke

Antiplatelet Strategies and Outcomes in Patients with Noncardioembolic Ischemic Stroke from a Real-World Study with a Five-Year Follow-Up

MRI Characterization in the Acute Phase of Experimental Subarachnoid Hemorrhage

Evolutional Characterization of Photochemically Induced Stroke in Rats: a Multimodality Imaging and Molecular Biological Study

Inhibition of Blood-Brain Barrier Disruption by an Apolipoprotein E-Mimetic Peptide Ameliorates Early Brain Injury in Experimental Subarachnoid Hemorrhage

Sex Differences in the Cerebral Collateral Circulation

DRα1-MOG-35-55 Reduces Permanent Ischemic Brain Injury

Uric Acid Is Protective After Cerebral Ischemia/Reperfusion in Hyperglycemic Mice

Translational Stroke Research : Volume 8, Issue 2, April 2017

Translational Stroke Research : Volume 8, Issue 1, February 2017

Translational Stroke Research : Volume 7

Translational Stroke Research : Volume 6

Translational Stroke Research : Volume 5

Translational Stroke Research : Volume 4

Translational Stroke Research : Volume 3

Translational Stroke Research : Volume 2

Translational Stroke Research : Volume 1

A Systematic and Meta-Analysis of Mortality in Experimental Mouse Models Analyzing Delayed Cerebral Ischemia After Subarachnoid Hemorrhage

Content Provider	Springer Nature Link
Author	Kamp, Marcel A. Lieshout, Jasper H. van Dibué Adjei, Maxine Weber, Jasmin K. Schneider, Toni Restin, Tanja Fischer, Igor Steiger, Hans Jakob
Copyright Year	2017
Abstract	Animal models are established to display the pathophysiological changes following subarachnoid hemorrhage (SAH). The aim of the present study was to determine case fatality in mouse delayed cerebral ischemia (DCI) models, to compare mortality in mouse DCI models to case fatality in human SAH patients, and to identify factors influencing mouse mortality. A systematic search of the PubMed database was performed to identify all studies that assessed mouse DCI models. Mortality rates and predictor variables were extracted and compared to the human case fatality after SAH as previously reported. Predictors for mouse mortality were identified through multivariate analysis. Forty-eight studies were included in the quantitative analysis. The mean overall mortality rate was 21% in mouse DCI models. However, the time period between induction of SAH and evaluation of mortality rates is a significant variable influencing the mortality rate in mouse SAH models. The experimental SAH model was the only significant predictor for mouse mortality after 48 h. In contrast, neither the genetic background nor the anesthetic changed the case fatality rate. Mouse mortality at 24, 48, and 72 h after experimental SAH in DCI models was significantly lower than human case fatality following aneurysmal SAH. The mean overall mortality rate in mouse DCI models is significantly lower than human case fatality following aneurysmal SAH. However, time between SAH induction and evaluation is a significant variable influencing the mortality rate in mouse SAH models. Further analyses will be required to establish whether and to which extent different DCI models affect mortality and reflect human pathophysiology.
Starting Page	206
Ending Page	219
Page Count	14
File Format	PDF
ISSN	18684483
Journal	Translational Stroke Research
Volume Number	8
Issue Number	3
e-ISSN	1868601X
Language	English
Publisher	Springer US
Publisher Date	2017-01-30
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Subarachnoid hemorrhage SAH Mouse Mouse model Delayed cerebral ischemia DCI Mortality Neurosciences Neurology Cardiology Neurosurgery Vascular Surgery
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine Neuroscience Neurology (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Higher Cerebrospinal Fluid pH may Contribute to the Development of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage

The Role of Thromboinflammation in Delayed Cerebral Ischemia after Subarachnoid Hemorrhage

Current Management of Delayed Cerebral Ischemia: Update from Results of Recent Clinical Trials

Plasticity of Cerebrovascular Smooth Muscle Cells After Subarachnoid Hemorrhage

Cerebral Lactate Correlates with Early Onset Pneumonia after Aneurysmal SAH

Magnesium Sulfate Treatment Improves Outcome in Patients with Subarachnoid Hemorrhage: A Meta-analysis Study

Proposed Definition of Experimental Secondary Ischemia for Mouse Subarachnoid Hemorrhage.

A Non-Human Primate Model of Aneurismal Subarachnoid Hemorrhage (SAH)

Vascular Neural Network in Subarachnoid Hemorrhage

A Systematic and Meta-Analysis of Mortality in Experimental Mouse Models Analyzing Delayed Cerebral Ischemia After Subarachnoid Hemorrhage

Similar Documents

Higher Cerebrospinal Fluid pH may Contribute to the Development of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage

The Role of Thromboinflammation in Delayed Cerebral Ischemia after Subarachnoid Hemorrhage

Current Management of Delayed Cerebral Ischemia: Update from Results of Recent Clinical Trials

Plasticity of Cerebrovascular Smooth Muscle Cells After Subarachnoid Hemorrhage

Cerebral Lactate Correlates with Early Onset Pneumonia after Aneurysmal SAH

Magnesium Sulfate Treatment Improves Outcome in Patients with Subarachnoid Hemorrhage: A Meta-analysis Study

Proposed Definition of Experimental Secondary Ischemia for Mouse Subarachnoid Hemorrhage.

A Non-Human Primate Model of Aneurismal Subarachnoid Hemorrhage (SAH)

Vascular Neural Network in Subarachnoid Hemorrhage

A Systematic and Meta-Analysis of Mortality in Experimental Mouse Models Analyzing Delayed Cerebral Ischemia After Subarachnoid Hemorrhage