NDLI: A Post-stroke Therapeutic Regimen with Omega-3 Polyunsaturated Fatty Acids that Promotes White Matter Integrity and Beneficial Microglial Responses after Cerebral Ischemia

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Delayed Docosahexaenoic Acid Treatment Combined with Dietary Supplementation of Omega-3 Fatty Acids Promotes Long-Term Neurovascular Restoration After Ischemic Stroke

Dimethyl Fumarate and Monomethyl Fumarate Promote Post-Ischemic Recovery in Mice

A Post-stroke Therapeutic Regimen with Omega-3 Polyunsaturated Fatty Acids that Promotes White Matter Integrity and Beneficial Microglial Responses after Cerebral Ischemia

Translational Stroke Research : Volume 7, Issue 5, October 2016

Translational Stroke Research : Volume 7, Issue 4, August 2016

Translational Stroke Research : Volume 7, Issue 3, June 2016

Translational Stroke Research : Volume 7, Issue 2, April 2016

Translational Stroke Research : Volume 7, Issue 1, February 2016

Translational Stroke Research : Volume 6

Translational Stroke Research : Volume 5

Translational Stroke Research : Volume 4

Translational Stroke Research : Volume 3

Translational Stroke Research : Volume 2

Translational Stroke Research : Volume 1

A Post-stroke Therapeutic Regimen with Omega-3 Polyunsaturated Fatty Acids that Promotes White Matter Integrity and Beneficial Microglial Responses after Cerebral Ischemia

Content Provider	Springer Nature Link
Author	Jiang, Xiaoyan Pu, Hongjian Hu, Xiaoming Wei, Zhishuo Hong, Dandan Zhang, Wenting Gao, Yanqin Chen, Jun Shi, Yejie
Copyright Year	2016
Abstract	White matter injury induced by ischemic stroke elicits sensorimotor impairments, which can be further deteriorated by persistent proinflammatory responses. We previously reported that delayed and repeated treatments with omega-3 polyunsaturated fatty acids (n-3 PUFAs) improve spatial cognitive functions and hippocampal integrity after ischemic stroke. In the present study, we report a post-stroke n-3 PUFA therapeutic regimen that not only confers protection against neuronal loss in the gray matter but also promotes white matter integrity. Beginning 2 h after 60 min of middle cerebral artery occlusion (MCAO), mice were randomly assigned to receive intraperitoneal docosahexaenoic acid (DHA) injections (10 mg/kg, daily for 14 days), alone or in combination with dietary fish oil (FO) supplements starting 5 days after MCAO. Sensorimotor functions, gray and white matter injury, and microglial responses were examined up to 28 days after MCAO. Our results showed that DHA and FO combined treatment-facilitated long-term sensorimotor recovery and demonstrated greater beneficial effect than DHA injections alone. Mechanistically, n-3 PUFAs not only offered direct protection on white matter components, such as oligodendrocytes, but also potentiated microglial M2 polarization, which may be important for white matter repair. Notably, the improved white matter integrity and increased M2 microglia were strongly linked to the mitigation of sensorimotor deficits after stroke upon n-3 PUFA treatments. Together, our results suggest that post-stroke DHA injections in combination with FO dietary supplement benefit white matter restoration and microglial responses, thereby dictating long-term functional improvements.
Starting Page	548
Ending Page	561
Page Count	14
File Format	PDF
ISSN	18684483
Journal	Translational Stroke Research
Volume Number	7
Issue Number	6
e-ISSN	1868601X
Language	English
Publisher	Springer US
Publisher Date	2016-10-07
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Myelin Oligodendrogenesis Corpus callosum Microglial polarization Neurosciences Neurology Cardiology Neurosurgery Vascular Surgery
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine Neuroscience Neurology (clinical)

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A Post-stroke Therapeutic Regimen with Omega-3 Polyunsaturated Fatty Acids that Promotes White Matter Integrity and Beneficial Microglial Responses after Cerebral Ischemia