NDLI: Methylphenidate Treatment Leads to Abnormalities on Krebs Cycle Enzymes in the Brain of Young and Adult Rats

Content Provider	Springer Nature Link
Author	Réus, Gislaine Z. Scaini, Giselli Furlanetto, Camila B. Morais, Meline O. S. Jeremias, Isabela C. Mello Santos, Lis Mairá Freitas, Karolina V. Quevedo, João Streck, Emilio L.
Copyright Year	2013
Abstract	Studies have shown a relationship between energy metabolism and methylphenidate (MPH); however, there are no studies evaluating the effects of MPH in Krebs cycle. So, we investigated if MPH treatment could alter the activity of citrate synthase (CS), malate dehydrogenase (MD), and isocitrate dehydrogenase (ID) in the brain of young and adult Wistar rats. Our results showed that MPH (2 and 10 mg/kg) reduced CS in the striatum and prefrontal cortex (PF), with MPH at all doses in the cerebellum and hippocampus after chronic treatment in young rats. In adult rats the CS was reduced in the cerebellum after acute treatment with MPH at all doses, and after chronic treatment in the PF and cerebellum with MPH (10 mg/kg), and in the hippocampus with MPH (2 and 10 mg/kg). The ID decreased in the hippocampus and striatum with MPH (2 and 10 mg/kg), and in the cortex (10 mg/kg) after acute treatment in young rats. In adult rats acute treatment with MPH (2 and 10 mg/kg) reduced ID in the cerebellum, and with MPH (10 mg/kg) in the cortex; chronic treatment with MPH (10 mg/kg) decreased ID in the PF; with MPH (2 and 10 mg/kg) in the cerebellum, and with MPH at all doses in the hippocampus. The MD did not alter. In conclusion, our results suggest that MPH can alter enzymes of Krebs cycle in brain areas involved with circuits related with attention deficit hyperactivity disorder; however, such effects depend on age of animal and treatment regime.
Starting Page	251
Ending Page	257
Page Count	7
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	24
Issue Number	2
e-ISSN	14763524
Language	English
Publisher	Springer-Verlag
Publisher Date	2013-02-20
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Methylphenidate Citrate synthase Malate dehydrogenase Isocitrate dehydrogenase Neurosciences Neurology Neurochemistry Pharmacology/Toxicology Neurobiology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cell Cycle Activation and CNS Injury

Neonatal Iron Treatment Increases Apoptotic Markers in Hippocampal and Cortical Areas of Adult Rats

Ontogenetic noradrenergic lesion alters histaminergic activity in adult rats

Perinatal Manganese Exposure and Hydroxyl Radical Formation in Rat Brain

Topiramate Confers Neuroprotection Against Methylphenidate-Induced Neurodegeneration in Dentate Gyrus and CA1 Regions of Hippocampus via CREB/BDNF Pathway in Rats

Neonatal DSP-4 Treatment Modifies Antinociceptive Effects of the CB$_{1}$ Receptor Agonist Methanandamide in Adult Rats

Speaker abstracts

Ethylene Glycol Ethers Induce Oxidative Stress in the Rat Brain

Methamphetamine is not Toxic but Disrupts the Cell Cycle of Blood–Brain Barrier Endothelial Cells

Methylphenidate Treatment Leads to Abnormalities on Krebs Cycle Enzymes in the Brain of Young and Adult Rats

Similar Documents

Cell Cycle Activation and CNS Injury

Neonatal Iron Treatment Increases Apoptotic Markers in Hippocampal and Cortical Areas of Adult Rats

Ontogenetic noradrenergic lesion alters histaminergic activity in adult rats

Perinatal Manganese Exposure and Hydroxyl Radical Formation in Rat Brain

Topiramate Confers Neuroprotection Against Methylphenidate-Induced Neurodegeneration in Dentate Gyrus and CA1 Regions of Hippocampus via CREB/BDNF Pathway in Rats

Neonatal DSP-4 Treatment Modifies Antinociceptive Effects of the CB$_{1}$ Receptor Agonist Methanandamide in Adult Rats

Speaker abstracts

Ethylene Glycol Ethers Induce Oxidative Stress in the Rat Brain

Methamphetamine is not Toxic but Disrupts the Cell Cycle of Blood–Brain Barrier Endothelial Cells

Methylphenidate Treatment Leads to Abnormalities on Krebs Cycle Enzymes in the Brain of Young and Adult Rats