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| Content Provider | Springer Nature Link |
|---|---|
| Author | Tolosa, Amparo Zhou, Xiaolai Spittau, Björn Krieglstein, Kerstin |
| Copyright Year | 2012 |
| Abstract | Cellular models for Parkinson’s disease (PD) represent a fast and efficient tool in the screening for drug candidates and factors involved in the disease pathogenesis. The objective of this study was to establish and characterize a survival and toxic cellular model for PD by culturing dopaminergic neurons from embryonic chicken ventral midbrain. We show that as in rodents, the common neurotrophic factors—brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and fibroblast growth factor 2 (FGF2)—are able to support the survival of chicken midbrain dopaminergic neurons. Furthermore, after treatment with MPP$^{+}$ or rotenone as in vitro models for PD, the number of tyrosine hydroxylase-positive cells decreased drastically. This effect could be significantly rescued by treatment with BDNF or GDNF. Together, our results indicate that mechanisms of neuroprotection of dopaminergic neurons are conserved between chicken and mammals. This supports the use of primary culture from chicken embryonic midbrain as a suitable tool for the study of neuroprotection in vitro. |
| Starting Page | 119 |
| Ending Page | 129 |
| Page Count | 11 |
| File Format | |
| ISSN | 10298428 |
| Journal | Neurotoxicity Research |
| Volume Number | 24 |
| Issue Number | 2 |
| e-ISSN | 14763524 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2012-12-13 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Dopaminergic neurons Embryonic chicken midbrain Neuroprotection Parkinson’s disease Neurosciences Neurology Neurochemistry Pharmacology/Toxicology Neurobiology Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Toxicology |
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