NDLI: Thioperamide, an H$_{3}$ Receptor Antagonist Prevents [$^{3}$H]Glucose Uptake in Brain of Adult Rats Lesioned as Neonates with 5,7-Dihydroxytryptamine

Content Provider	Springer Nature Link
Author	Jośko, Jadwiga Drab, Jacek Nowak, Przemysław Szkilnik, Ryszard Körőssy, Èva Boroń, Dariusz Brus, Halina Kostrzewa, Richard M. Brus, Ryszard
Copyright Year	2010
Abstract	As a first attempt at exploring an association between histaminergic and serotoninergic neuronal phenotypes in glucose regulation, the influence of the histamine H$_{3}$ receptor antagonist thioperamide on glucose uptake by brain was determined in rats in which the serotoninergic innervations of brain was largely destroyed perinatally. Male Wistar rats were initially treated on the 3rd day after birth with the serotoninergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) (75 μg icv) or saline vehicle (10 μl icv). At 8 weeks lesioned and control rats were terminated in order to validate the effectiveness of 5,7-DHT: reduction in 5-HT and 5-HIAA by 83–91% and 69–83% in striatum, frontal cortex, and hippocampus (HPLC/ED method). Other groups of rats were pretreated with thioperamide (5.0 mg/kg ip) or saline vehicle 60 min prior to 6-[$^{3}$H]-D-glucose (500 μCi/kg ip). Fifteen-min later rats were decapitated and brains were excised and dissected to remove frontal cortex, striatum, hippocampus, thalamus/hypothalamus, pons, and cerebellum. Liquid scintillation spectroscopy was used to determine that [$^{3}$H]glucose uptake, which was enhanced in 5,7-DHT lesioned rats in cortex (by 88%), hippocampus, thalamus/hypothalamus, pons and cerebellum (each by 47–56%), and in striatum (by 35%). In contrast, thioperamide prevented the enhancement in [$^{3}$H]glucose uptake in all brain regions of 5,7-DHT neonatally lesioned rats; and [$^{3}$H]glucose levels were significantly different in all brain regions (except thalamus/hypothalamus) in thioperamide-versus saline-treated rats. These findings indicate a functional association between histaminergic and serotoninergic systems in brain in relation to glucose regulation.
Starting Page	93
Ending Page	96
Page Count	4
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	20
Issue Number	1
e-ISSN	14763524
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-09-14
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	5,7-DHT 5-HT 5-HIAA Thioperamide D-$^{3}$H-6-glucose Brain Rats Neurochemistry Neurosciences Cell Biology Neurobiology Pharmacology/Toxicology Neurology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

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Thioperamide, an H$_{3}$ Receptor Antagonist Prevents [$^{3}$H]Glucose Uptake in Brain of Adult Rats Lesioned as Neonates with 5,7-Dihydroxytryptamine