NDLI: Ontogenetic Serotoninergic Lesioning Alters Histaminergic Activity in Rats in Adulthood

Content Provider	Springer Nature Link
Author	Jośko, Jadwiga Drab, Jacek Jochem, Jerzy Nowak, Przemysław Szkilnik, Ryszard Korossy Mruk, Eva Boroń, Dariusz Kostrzewa, Richard M. Brus, Halina Brus, Ryszard
Copyright Year	2010
Abstract	The aim of this study was to determine histamine content in the brain and the effect of histamine receptor antagonists on behavior of adult rats lesioned as neonates with the serotonin (5-HT) neurotoxin 5,7-dihydroxytryptamine (5,7-DHT). At 3 days after birth Wistar rats were pretreated with desipramine (20 mg/kg ip) before bilateral icv administration of 5,7-DHT (37.5 μg base on each side) or saline—ascorbic (0.1%) vehicle (control). At 10 week levels of 5-HT and its metabolite 5-hydroxyindole acetic acid (5-HIAA) were determined in frontal cortex, striatum, and hippocampus by an HPLC/ED technique. In the hypothalamus, frontal cortex, hippocampus and medulla oblongata, the level of histamine was analyzed by an immunoenzymatic method. Behavioral observations (locomotion, exploratory-, oral-, and stereotyped activity) were performed, and effects of DA receptor agonists (SKF 38393, apomorphine) and histamine receptor antagonists S(+)chlorpheniramine (H$_{1}$), cimetidine (H$_{2}$), and thioperamide (H$_{3}$) were determined. We confirmed that 5,7-DHT profoundly reduced contents of 5-HT and 5-HIAA in the brain in adulthood. Histamine content was also reduced in all examined brain regions. Moreover, in 5,7-DHT-lesioned rats the locomotor and oral activity responses to thioperamide were altered, and apomorphine-induced stereotype was intensified. From the above, we conclude that an intact central serotoninergic system modulates histamine H$_{3}$ receptor antagonist effects on the dopaminergic neurons in rats.
Starting Page	103
Ending Page	108
Page Count	6
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	20
Issue Number	2
e-ISSN	14763524
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-09-14
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	5,7-DHT 5-HT 5-HIAA Histamine Histamine receptor antagonist Brain Behavior Rats Cell Biology Neurosciences Pharmacology/Toxicology Neurobiology Neurochemistry Neurology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

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