NDLI: Repeated Application of 4-Aminopyridine Provoke an Increase in Entorhinal Cortex Excitability and Rearrange AMPA and Kainate Receptors

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Repeated Application of 4-Aminopyridine Provoke an Increase in Entorhinal Cortex Excitability and Rearrange AMPA and Kainate Receptors

Content Provider	Springer Nature Link
Author	Borbély, Sándor Czégé, Dávid Molnár, Elek Dobó, Endre Mihály, András Világi, Ildikó
Copyright Year	2015
Abstract	Entorhinal cortex is a highly epilepsy-prone brain region. Effects of repetitive seizures on ionotropic glutamate receptors (iGluRs) were investigated in rat entorhinal cortex slices. Seizures were induced by daily administration of 4-aminopyridine (4-AP). Electrophysiological, pharmacological and histological investigations were carried out to determine changes in synaptic efficacy and in sensitivity of iGluRs due to recurring seizures. Repeated 4-AP-induced seizures increased the amplitude of evoked synaptic field responses in rat entorhinal cortical slices. While vulnerability to inhibition of AMPA receptors by the specific antagonist GYKI 52466 was slightly reduced, responsiveness to NMDA receptor antagonist APV remained unaffected. Testing of bivalent cation permeability of iGluRs revealed reduced Ca$^{2+}$-influx through non-NMDA receptors. According to the semi-quantitative histoblot analysis GluA1–4, GluA1, GluA2, GluK5, GluN1 and GluN2A subunit protein expression differently altered. While there was a marked decrease in the level of GluA1–4, GluA2 and GluK5 receptor subunits, GluA1 and GluN2A protein levels moderately increased. The results indicate that brief convulsions, repeated daily for 10 days can increase overall entorhinal cortex excitability despite a reduction in AMPA/kainate receptor activity, probably through the alteration of local network susceptibility.
Starting Page	441
Ending Page	452
Page Count	12
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	27
Issue Number	4
e-ISSN	14763524
Language	English
Publisher	Springer US
Publisher Date	2015-01-10
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Seizure Brain slice 4-Aminopyridine Entorhinal cortex Glutamate receptor Neurosciences Neurology Neurochemistry Pharmacology/Toxicology Neurobiology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

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