NDLI: Glutamate receptors modulate oxidative stress in neuronal cells. A mini-review

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Neurotoxicity Research : Volume 6, Issue 6, January 2004

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Glutamate receptors modulate oxidative stress in neuronal cells. A mini-review

Content Provider	Springer Nature Link
Author	Boldyrev, A. Bulygina, E. Makhro, A.
Copyright Year	2004
Abstract	Multiple lines of evidence demonstrate that reactive oxygen species (ROS) are involved in regulation of normal cell metabolism as second messengers. Under extreme conditions, these molecules induce oxidative stress, which may stimulate (or accompany) a number of neurodegenerative processes. In the glutamatergic system, ROS levels are under control of ionotropic and metabotropic glutamate receptors, which modulate ion fluxes through the neuronal membrane. The Na$^{+}$/K$^{+}$-pump is also one of the important participants affecting stationary ROS levels through several distinct mechanisms. This review describes the involvement of the Na$^{+}$/K$^{+}$-pump in intracellular signaling mechanisms via cross-talk between the pump and glutamate receptors in cerebellum granule cells. Selective dysfunction of mGlu II receptors may also lead to abnormal protein phosphorylation (i.e., tau phosphorylation), culminating in neurodegenerative disorders (i.e., Alzheimer disease). Also, unregulated production of intracellular ROS resulting from an imbalance of ionotropic and metabotropic receptors may activate one or more protein kinases. In summary, Glu receptor dysfunction, leading to a deficit in glutamate-mediated signal transduction may represent one of the earliest stages of neurodegenerative disorders. The Na$^{+}$/K$^{+}$-pump is able to prevent over-production of intracellular ROS, thus increasing oxidative stability of neuronal cells.
Starting Page	581
Ending Page	587
Page Count	7
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	6
Issue Number	7-8
e-ISSN	14763524
Language	English
Publisher	Springer-Verlag
Publisher Date	2004-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ionotropic receptors Metabotropic receptors Glutamate Na/K-ATPase Neurons Oxidative stress Reactive oxygen species Neurosciences Pharmaceutical Sciences/Technology Neurology Neurochemistry Pharmacology/Toxicology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

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