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Neurotoxins and neurotoxic species implicated in neurodegeneration

Neurotoxicity Research : Volume 6, Issue 6, January 2004

Neurotoxicity Research : Volume 6, Issue 5, January 2004

Neurotoxicity Research : Volume 6, Issue 4, January 2004

Neurotoxicity Research : Volume 6, Issue 3, January 2004

Neurotoxicity Research : Volume 6, Issue 2, January 2004

Neurotoxicity Research : Volume 6, Issue 1, January 2004

Neurotoxicity Research : Volume 5

Neurotoxicity Research : Volume 4

Neurotoxicity Research : Volume 3

Neurotoxicity Research : Volume 2

Neurotoxicity Research : Volume 1

Neurotoxins and neurotoxic species implicated in neurodegeneration

Content Provider	Springer Nature Link
Author	Segura Aguilar, Juan Kostrzewa, Richard M.
Copyright Year	2004
Abstract	Neurotoxins, in the general sense, represent novel chemical structures which when administered in vivo orin vitro, are capable of producing neuronal damage or neurodegeneration—with some degree of specificity relating to neuronal phenotype or populations of neurons with specific characteristics (i.e., receptor type, ion channel type, astrocyte-dependence, etc.). The broader term ‘neurotoxin’ includes this categorization but extends the term to include intra- or extracellular mediators involved in the neurodegenerative event, including necrotic and apoptotic factors. Moreover, as it is recognized that astrocytes are essential supportive satellite cells for neurons, and because damage to these cells ultimately affects neuronal function, the term ‘neurotoxin’ might reasonably be extended to include those chemical species which also adversely affect astrocytes. This review is intended to highlight developments that have occurred in the field of ‘neurotoxins’ during the past 5 years, including MPTP/MPP$^{+}$, 6-hydroxydopamine (6-OHDA), meth-amphetamine; salsolinol; leukoaminochrome-o-semi-quinone; rotenone; iron; paraquat; HPP$^{+}$; veratridine; soman; glutamate; kainate; 3-nitropropionic acid; peroxynitrite anion; and metals (copper, manganese, lead, mercury). Neurotoxins represent tools to help elucidate intra- and extra-cellular processes involved in neuronal necrosis and apoptosis, so that drugs can be developed towards targets that interrupt the processes leading towards neuronal death.
Starting Page	615
Ending Page	630
Page Count	16
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	6
Issue Number	7-8
e-ISSN	14763524
Language	English
Publisher	Springer-Verlag
Publisher Date	2004-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurotoxins Neurodegeneration Necrosis Apoptosis MPTP 6-OHDA Methamphetamine Rotenone Leukoaminochrome-o-semiquinone Salsolinol Paraquat Veratridine Peroxynitrite anion 3-Nitropropionic acid Soman Glutamate Kainate Domoate MPP$^{+}$ HPP$^{+}$ Iron Copper Manganese Lead Mercury Neurosciences Pharmaceutical Sciences/Technology Neurology Neurochemistry Pharmacology/Toxicology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

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Neurotoxins and neurotoxicity mechanisms. an overview

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Divergent Mechanisms of Paraquat, MPP+, and Rotenone Toxicity: Oxidation of Thioredoxin and Caspase-3 Activation

β-Cells Different Vulnerability to the Parkinsonian Neurotoxins Rotenone, 1-Methyl-4-phenylpyridinium $(MPP^{+}$) and 6-Hydroxydopamine (6-OHDA)

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