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Dopamine agonists and analogues have an antiproliferative effect on CHO-K1 cells

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Neurotoxicity Research : Volume 1, Issue 3, September 1999

Neurotoxicity Research : Volume 1, Issue 2, June 1999

Neurotoxicity Research : Volume 1, Issue 1, March 1999

Dopamine agonists and analogues have an antiproliferative effect on CHO-K1 cells

Content Provider	Springer Nature Link
Author	Maggio, Roberto Armogida, Marianna Scarselli, Marco Salvadori, Federica Longoni, Biancamaria Pardini, Carla Chiarenza, Andrea Chiacchio, Serena Vaglini, Francesca Bernardini, Renato Colzi, Anna Corsini, Giovanni U.
Copyright Year	1999
Abstract	Epidemiological studies have shown a reduced incidence of cancer in Parkinson’s disease. Since nearly all parkinsonian patients with clinical impairment are treated with L-β-3,4-dihydroxyphenylalanine (L-DOPA) and dopamine (DA)ergic agonists, a possibility exists that these therapeutic agents can influence the risk of cancer. We studied the antiproliferative effect of these therapeutic agents (and substances structurally correlated) on Chinese hamster ovary (CHO)-K1 cell growth. Among the compounds tested, apomorphine proved to be the most potent inhibitor of CHO-K1 cell growth, with an EC$_{50}$ of 3.35 ± 0.12 μM. The apomorphine analogues, apocodeine and hydroxyethylnorapomorphine, were less active as inhibitors of CHO-K1 cell growth. The activity of DA, 6-hydroxydopamine (6-OHDA), phe-nylethylamine (PEA), L-DOPA and bromocriptine as antiproliferative was one order of magnitude lower than that of apomorphine while pergolide was ineffective. To test whether or not the oxidative potential of these compounds was important for their antiproliferative effect, several antioxidants were assayed. Among them, glutathione (GSH) and dithio-threitol (DTT) were effective in reversing the antiproliferative effect of apomorphine, DA, 6-OHDA and PEA, conversely they did not work with bromocriptine. GSH and DTT are sulphydryl-reducing agents; while their effect could explain the efficacy against apomorphine, DA and 6-OHDA, it is difficult to understand why they should have any effect on PEA as this substance does not react with sulphydryl groups. The oxidative potential as a mechanism of action was also questioned by the results obtained with dihydrorhodamine 123, a probe that changes its fluorescent emission wave when oxidized. None of the compounds, with the exception of 6-OHDA, had any effect on the fluorescent emission wave of the probe at the maximal concentrations used to inhibit CHO-K1 cell growth. At concentrations five times higher, apomorphine and DA generated reactive oxygen species but PEA and bromocriptine did not. These data demonstrate that the antiproliferative effect of these compounds is not due to their oxidative potential, but another mechanism must be postulated.
Starting Page	285
Ending Page	297
Page Count	13
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	1
Issue Number	4
e-ISSN	14763524
Language	English
Publisher	Springer-Verlag
Publisher Date	1999-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Antiproliferative Apomorphine Bromocriptine Dopamine Chinese hamster ovary cell (CHO) L-DOPA Parkinson’s disease Pergolide Neurosciences Pharmaceutical Sciences/Technology Neurology Neurochemistry Pharmacology/Toxicology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

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Dopamine agonists and analogues have an antiproliferative effect on CHO-K1 cells