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Neurotoxicity Research : Volume 1, Issue 3, September 1999

Neurotoxicity Research : Volume 1, Issue 2, June 1999

Neurotoxicity Research : Volume 1, Issue 1, March 1999

Effects of clonidine and α-adrenoceptor antagonists on motor activity in DSP4-treated mice II: Interactions with apomorphine

Content Provider	Springer Nature Link
Author	Fredriksson, Anders Archer, Trevor
Copyright Year	1999
Abstract	Adult mice were administered either the noradrenaline (NA) neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine, (DSP4), or distilled water (control), 10–12 days before motor activity testing, and 6 h before testing all the mice were administered reserpine (10mg/kg), the monoamine-depleting agent. The interactive effects of (I) clonidine, the α$_{2}$-adrenoceptor agonist, with the dopamine (DA) agonist, apomorphine, and the α$_{2}$-antagonist, yohimbine, and (II) with either yohimbine or the α$_{1}$-antagonist, prazosin, upon motor behaviour in activity test chambers were studied in reserpinized DSP4-treated and control mice. It was shown that apomorphine (3mg/kg) increased locomotor and total activity in both reserpinized DSP4-treated and control mice but the effect was attenuated in the DSP4 mice. Coadministration of clonidine (3 mg/kg) with apomorphine potentiated the effects of apomorphine on motor activity and this effect was enhanced markedly by DSP4 pretreatment. Yohimbine (10 mg/kg) antagonised the motor activity-stimulating effects of apomorphine in both DSP4-treated and control mice. Co-administration of clonidine with apomorphine, following yohimbine, restored motor activity levels to those obtained in the absence of yohimbine and this effect upon locomotor activity was enhanced by DSP4 pretreatment. The effects of clonidine on motor activity were enhanced by NA-denervation. Prazosin (3 mg/kg) enhanced the locomotor activity of both reserpinized DSP4-treated and control mice after the initial 30-mm period but was not affected by DSP4 treatment. Analysis of post-decapitation convulsions (PDCs) indicated loss of the reflex by DSP4 pretreatment. Reserpine pretreatment abolished the initial, exploratory phase (30 min) of motor activity. These results demonstrate interactions between NA and DA systems that may bear eventual relevance to neurologic disorders such as parkinsonism.
Starting Page	249
Ending Page	259
Page Count	11
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	1
Issue Number	4
e-ISSN	14763524
Language	English
Publisher	Springer-Verlag
Publisher Date	1999-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	DSP4 Control Reserpine Locomotion Total activity Clonidine Apomorphine Co-administration Enhancement Yohimbine Antagonism Prazosin Supersensitivity Attenuation PDCs Movement disorders Mice Neurosciences Pharmaceutical Sciences/Technology Neurology Neurochemistry Pharmacology/Toxicology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

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