NDLI: Schizopsychotic symptom-profiles and biomarkers: Beacons in diagnostic labyrinths

Content Provider	Springer Nature Link
Author	Palomo, Tomas Kostrzewa, Richard M. Beninger, Richard J. Archer, Trevor
Copyright Year	2008
Abstract	Several avenues of investigation through which the ‘labyrinths’ of schizopsychotic diagnosis may be examined, are offered by the consideration of the ‘beacons’ of symptom-profiles and biomarkers. Neurodevelopmental issues and risk assessment, neurocognitive factors of predictive necessity, supersensitivity in neurotransmitter systems, the implications of prodromal expressions of the disorder, functional dysconnectivity arising from prefrontal to diverse regional patterns and circuits with a neurodevelopmental origin, and heritable gene characteristics are viewed against the backdrop of the schizophrenia spectrum disorders. The associations between adolescent-adult use of cannabis, on the one hand, and, alternatively, the prevalence of chromosomal abnormalities,e.g., GRIK4 andNPAS3, and mental retardation, on the other hand, with the symptom-profiles of schizopsychosis provide further evidence of emerging biomarkers of biological inheritance factors. The involvement of dopamine D$_{1}$ and D$_{2}$ receptors, particularly in prefrontal region, with regard to functional integrity of cognitive systems is reviewed. It would appear that considerations of these disorders imply that one essential hub around which much of the neuropathology revolves may be observed in the various expressions of the cognitive and structural insufficiency.
Starting Page	79
Ending Page	96
Page Count	18
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	14
Issue Number	2-3
e-ISSN	14763524
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Schizopsychosis Regional vulnerability Functional dysconnectivity Premorbidity Stereotypy Neurocognition Chromosomal abnormality Cannabis use Supersensitivity Neurosciences Pharmaceutical Sciences/Technology Neurology Neurochemistry Pharmacology/Toxicology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

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