NDLI: Dopamine receptor supersensitivity: An outcome and index of neurotoxicity

Content Provider	Springer Nature Link
Author	Kostrzewa, Richard M. Kostrzewa, John P. Brus, Ryszard
Copyright Year	2003
Abstract	The characteristics feature of neurotoxicity is a definable lesion which can account for observed deficits, corresponding to loss of nuclei or axonal fibers normally comprising a specific pathway or tract. However, with ontogenetic lesions, the operative definition fails. In rats lesioned as neonates with 6-hydroxydopamine (6-OHDA), near-total destruction of dopamine-(DA-) containing nerves is produced, and this itself is definable. However, the most prominent feature of rats so-lesioned is the DA receptor supersensitivity (DARSS) that develops and then persists throughtout the lifespan. DA D$_{1}$ receptors show overt supersensitivity to agonists producing vacuous chewing movements (VCMs), while D$_{1}$ receptors associated with locomotor activity have a latent supersensitivity that must be unmasked by repeated D$_{1}$ or D$_{2}$ agonist treatments — a ‘priming’ phenomenon. This D$_{1}$ DARSS is not usually associated in either a change in D$_{1}$ receptor number (B$_{max}$) or affinity (K$_{d}$). In contrast to D$_{1}$ DARSS, D$_{2}$ receptors are not so predictably supersensitized by a lession of DA neurons. In reality, the permanently exaggerated response to an agonist by supersensitized receptors isper se a manifestation of neurotoxicity. Despite dramatic behavioral responses mediated by supersensitized receptors, DARSS has not been easy to correlate with enhanced production of second messengers or early response genes. Altered signaling (i.e., neuronal cross-talk) in defined pathways may represent the mechanism that produces so-called receptor supersensitization. Longlived agonist-induced behavioral abnormality, with or without anatomic evidence of a neuronal lesion, is one of the products of DA D$_{1}$ receptor supersensitization — it self an index of neurotoxicity.
Starting Page	111
Ending Page	117
Page Count	7
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	5
Issue Number	1-2
e-ISSN	14763524
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Dopamine 6-Hydroxydopamine Neurotoxicity Receptor supersensitivity Receptor priming Neurosciences Pharmaceutical Sciences/Technology Neurology Neurochemistry Pharmacology/Toxicology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Dopamine receptor supersensitivity: Development, mechanisms, presentation, and clinical applicability

Dopamine D$_{2}$ agonist priming in intact and dopamine-lesioned rats

Modeling tardive dyskinesia: Predictive 5-HT$_{2C}$ receptor antagonist treatment

Ontogenetic quinpirole treatments fail to prime for D$_{2}$ agonist-enhancement of locomotor activity in 6-hydroxydopamine-lesioned rats

Behavioural supersensitivity following neonatal 6-hydroxydopamine: Attenuation by MK-801

Stereotypic Progressions in Psychotic Behavior

Neonatal 6-Hydroxydopamine Lesioning Enhances Quinpirole-Induced Vertical Jumping in Rats that were Quinpirole Primed During Postnatal Ontogeny

The 6-Hydroxydopamine model of parkinson’s disease

One-Electron Reduction of 6-Hydroxydopamine Quinone is Essential in 6-Hydroxydopamine Neurotoxicity

Dopamine receptor supersensitivity: An outcome and index of neurotoxicity

Similar Documents

Dopamine receptor supersensitivity: Development, mechanisms, presentation, and clinical applicability

Dopamine D$_{2}$ agonist priming in intact and dopamine-lesioned rats

Modeling tardive dyskinesia: Predictive 5-HT$_{2C}$ receptor antagonist treatment

Ontogenetic quinpirole treatments fail to prime for D$_{2}$ agonist-enhancement of locomotor activity in 6-hydroxydopamine-lesioned rats

Behavioural supersensitivity following neonatal 6-hydroxydopamine: Attenuation by MK-801

Stereotypic Progressions in Psychotic Behavior

Neonatal 6-Hydroxydopamine Lesioning Enhances Quinpirole-Induced Vertical Jumping in Rats that were Quinpirole Primed During Postnatal Ontogeny

The 6-Hydroxydopamine model of parkinson’s disease

One-Electron Reduction of 6-Hydroxydopamine Quinone is Essential in 6-Hydroxydopamine Neurotoxicity

Dopamine receptor supersensitivity: An outcome and index of neurotoxicity