NDLI: Neonatal dopamine depletion induces changes in morphogenesis and gene expression in the developing cortex

Content Provider	Springer Nature Link
Author	Krasnova, Irina N. Betts, Elizabeth S. Dada, Abiola Jefferson, Akilah Ladenheim, Bruce Becker, Kevin G. Cadet, Jean Lud Hohmann, Christine F.
Copyright Year	2007
Abstract	The mesocorticolimbic dopamine (DA) system is implicated in mental health disorders affecting attention, impulse inhibition and other cognitive functions. It has also been involved in the regulation of cortical morphogenesis. The present study uses focal injections of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle of BALB/c mice to examine morphological, behavioral and transcriptional responses to selective DA deficit in the fronto-parietal cortex. Mice that received injections of 6-OHDA on postnatal day 1 (PND1) showed reduction in DA levels in their cortices at PND7. Histological analysis at PND120 revealed increased fronto-cortical width, but decreased width of somatosensory parietal cortex. Open field object recognition suggested impaired response inhibition in adult mice after 6-OHDA treatment. Transcriptional analyses using 17K mouse microarrays showed that such lesions caused up-regulation of 100 genes in the cortex at PND7. Notably, among these genes are Sema3A which plays a repulsive role in axonal guidance, RhoD which inhibits dendritic growth and tubulin β5 microtubule subunit. In contrast, 127 genes were down-regulated, including CCTε and CCTζ that play roles in actin and tubulin folding. Thus, neonatal DA depletion affects transcripts involved in control of cytoskeletal formation and pathway finding, instrumental for normal differentiation and synaptogenesis. The observed gene expression changes are consistent with histological cortical and behavioral impairments in the adult mice treated with 6-OHDA on PND1. Our results point towards specific molecular targets that might be involved in disease process mediated by altered developmental DA regulation.
Starting Page	107
Ending Page	130
Page Count	24
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	11
Issue Number	2
e-ISSN	14763524
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cerebral cortex Dopamine Gene expression 6-Hydroxydopamine Microarray Morphology Neurosciences Pharmaceutical Sciences/Technology Neurology Neurochemistry Pharmacology/Toxicology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Behavioural supersensitivity following neonatal 6-hydroxydopamine: Attenuation by MK-801

Dopamine receptor supersensitivity: An outcome and index of neurotoxicity

The 6-Hydroxydopamine model of parkinson’s disease

Neonatal 6-hydroxydopamine-induced hypo/hyperactivity: Blockade by Dopamine reuptake Inhibitors and effect of acute D-amphetamine

Functional deficits following neonatal dopamine depletion and Isolation housing: Circular water maze acquisition under pre-exposure conditions and motor activity

Time course of deficits in open field behavior after unilateral neostriatal 6-hydroxydopamine lesions

One-Electron Reduction of 6-Hydroxydopamine Quinone is Essential in 6-Hydroxydopamine Neurotoxicity

Effect of stress on prefrontal cortex function

Neonatal 6-Hydroxydopamine Lesioning Enhances Quinpirole-Induced Vertical Jumping in Rats that were Quinpirole Primed During Postnatal Ontogeny

Neonatal dopamine depletion induces changes in morphogenesis and gene expression in the developing cortex

Similar Documents

Behavioural supersensitivity following neonatal 6-hydroxydopamine: Attenuation by MK-801

Dopamine receptor supersensitivity: An outcome and index of neurotoxicity

The 6-Hydroxydopamine model of parkinson’s disease

Neonatal 6-hydroxydopamine-induced hypo/hyperactivity: Blockade by Dopamine reuptake Inhibitors and effect of acute D-amphetamine

Functional deficits following neonatal dopamine depletion and Isolation housing: Circular water maze acquisition under pre-exposure conditions and motor activity

Time course of deficits in open field behavior after unilateral neostriatal 6-hydroxydopamine lesions

One-Electron Reduction of 6-Hydroxydopamine Quinone is Essential in 6-Hydroxydopamine Neurotoxicity

Effect of stress on prefrontal cortex function

Neonatal 6-Hydroxydopamine Lesioning Enhances Quinpirole-Induced Vertical Jumping in Rats that were Quinpirole Primed During Postnatal Ontogeny

Neonatal dopamine depletion induces changes in morphogenesis and gene expression in the developing cortex