NDLI: Sertoli cell grafts for Huntington's disease. An opinion

Content Provider	Springer Nature Link
Author	Emerich, Dwaine F.
Copyright Year	2004
Abstract	The role of inflammation in CNS diseases is controversial, but growing evidence suggests that antiinflammatory agents can minimize and/or prevent neural degeneration and its associated behavioral consequences. Sertoli cells can be grafted into the CNS to locally deliver molecules with known trophic and anti-inflammatory effects on the surrounding tissue. When sertoli cells are grafted into the 3-nitropropionic acid (3-NP) model of Huntington's disease the protective effects are quite similar to those obtained using systemic treatments with NSAIDS (Salzberg-Benhouseet al., J. Pharmacol. Exp. Ther. 306:218–228, 2003). While these data alone do not provide unequivocal support for the notion that Sertoli cell grafts exert their beneficial effects via modulating local inflammation, they do provide an interesting convergence between data sets. The benefits of Sertoli cells grafts should be more thoroughly examined in animal models of inflammation.
Starting Page	567
Ending Page	567
Page Count	1
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	5
Issue Number	8
e-ISSN	14763524
Language	English
Publisher	Springer-Verlag
Publisher Date	2004-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Pharmaceutical Sciences/Technology Neurology Neurochemistry Pharmacology/Toxicology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

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