NDLI: Intravenous Immunoglobulin and Rituximab for Cerebellar Ataxia with Glutamic Acid Decarboxylase Autoantibodies

Content Provider	Springer Nature Link
Author	Planche, Vincent Marques, Ana Ulla, Miguel Ruivard, Marc Durif, Franck
Copyright Year	2013
Abstract	Cerebellar ataxia associated with glutamic acid decarboxylase autoantibodies (GAD-ab) is a rare and usually slow progressive disease with moderate to severe gait and limb ataxia, dysarthria, and nystagmus. The treatment for this condition is still being discussed. We report the cases of three patients with GAD-ab cerebellar ataxia treated successively with intravenous immunoglobulin (IVIg) and rituximab. Symptoms improved in one case after rituximab therapy and were stabilized in another after a combined therapy of IVIg and rituximab. The third patient continued to worsen despite these treatments. We conclude that IVIg and rituximab therapy could improve or stabilize GAD-ab cerebellar ataxia. Early treatment, the lack of cerebellar atrophy on magnetic resonance imaging, and a subacute onset of the symptoms could be decisive prognostic factors.
Starting Page	318
Ending Page	322
Page Count	5
File Format	PDF
ISSN	14734222
Journal	The Cerebellum
Volume Number	13
Issue Number	3
e-ISSN	14734230
Language	English
Publisher	Springer US
Publisher Date	2013-11-12
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Glutamic acid decarboxylase antibodies Cerebellar ataxia Gait disorders Intravenous immunoglobulin Rituximab Neuro-immunity Neurosciences Neurology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical)

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